Experiments to investigate the infectivity of Glossina palpalis fed on sleeping sickness patients under treatment / by Sir David Bruce [and others].

Date:
[1911]
Catalogue details

Licence: Public Domain Mark

Credit: Experiments to investigate the infectivity of Glossina palpalis fed on sleeping sickness patients under treatment / by Sir David Bruce [and others]. Source: Wellcome Collection.

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    Table IL—Transmission of Zrypanosoma gambicnse from Sleeping Sickness Patients, Class A, to Healthy Monkeys, an Interval of Time being allowed for the Development of the Trypanosomes in the Fly. No. of Novtot No. of No. of experi- ae Re sie flies fed on cen 7 a Mi 4 Hes Result. Remarks. | mens Peon patient. | monkey. 1941 7 days 2 125 6 50 _ Monkey remained | healthy. 1973 va 2 100 6 50 oil ei . 1969 1 month A; 100 7 50 — » 1995 a ” 4 130 4 50 | ma ” 2240 24 years P 75 4. 50 = ” 2252 2k ” ? 80 4 50 ae ” Remarks.—Reference to Table II will show that six patients in Class A stage of the disease were under treatment. Two of these had been under treatment for one weék, and had each received two injections of soamin, 0°01 gramme, combined with perchloride of mercury, 0°02 gramme. Two had been under treatment for one month, and had received four injections of soamin, 0°01 gramme, and perchloride of mercury, 0°02 gramme, per dose. Two cases had been under treatment for two and a-half years: the total quantity of drugs received being, in one case, atoxyl, 16:2 grammes, perchloride of mercury, 2°4 grammes, and orpiment, 8°6 grammes ; the other case had received 18°8 grammes of atoxyl, 2°4 grammes of perchloride of mercury, and 8°6 grammes of orpiment. Sleeping Sickness was not transmitted from any of these patients to monkeys by the flies. Two hundred and seventy-three flies were dissected between the 4th and 51st days after feeding upon infected patients, but no flies were found infected with flagellates. Only one patient belonging to Class D was available for these experiments. This patient had been under treatment for one and a-half years, and had been treated with a total quantity of 13-4 grammes atoxyl, 0:4 gramme perchloride of mercury, and 6°5 grammes orpiment. Flies were not infected from this case, and the disease was therefore not transmitted to a normal monkey.
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