A case of multiple myeloma (myelomatosis) with Bence-Jones proteid in the urine (myelopathic albumosuria of Bradshaw, Kahler's disease) and a summary of published cases of Bence-Jones albumosuria / by F. Parkes Weber ; with a report on the chemical pathology by R. Hutchison and J.J.R. Macleod.

  • Frederick Parkes Weber
Date:
1903
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Licence: In copyright

Credit: A case of multiple myeloma (myelomatosis) with Bence-Jones proteid in the urine (myelopathic albumosuria of Bradshaw, Kahler's disease) and a summary of published cases of Bence-Jones albumosuria / by F. Parkes Weber ; with a report on the chemical pathology by R. Hutchison and J.J.R. Macleod. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    MULTIPLE MYELOMA 73 Plate III.—Dr. Bradshaw’s patient (Case No. 10 in the Sum- mary) with multiple myeloma and Bence-Jones albumosuria, to illustrate the kyphosis. Reproduced by permission from Dr. Bradshaw’s paper in the ‘ Med.-Chir. Transactions,’ vol. lxxxi. Plate IV.—To show colour reaction of the granules and globules of the tumour-cells. ( Fig. 1.—Part of a section of the new growth (under oil immersion). A. Blood-vessel with thin walls filled with red blood-corpuscles. B. Cells resembling lymphocytes, c. Medium-sized globules in tumour-cell. D. Globules of various sizes free amongst the tumour- cells. E. Large globule, tlmee or four times larger than a red blood-corpuscle, enclosed in a tumour-cell. The section was stained with hasmatoxylin after Mann’s eosin and methyl-blue combination. The small granules in the tumour-cells are not seen. It will be observed that the globules, both those enclosed in tumour-cells and those lying free in the tissue, are stained differently to the red blood- corpuscles. In the big globule (e), however, the tint approaches more nearly that of the red corpuscles. The shape of the globules in question differs from that of the ved blood-corpuscles in being almost perfectly spherical. Fig. 2 (higher magnification).—A mulberry-like collection of globules, apparently formed in a single cell, of which the nucleus is visible. Fig. 3.—Two tumour-cells showing granules and characteristic excentric position of the nucleus, which is surrounded by a zone free from granules; a larger tumour-cell containing granules and globules of various sizes. This figure is a semi-diagrammatic representation from a section sent me by Professor R. Muir, stained with Mann’s eosin and methyl-blue combination without the additional htematoxylin which was employed in the preparations from which the first two figures were drawn. <3
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