beta-Iminazolylethylamine : a depressor constituent of intestinal mucosa / by G. Barger and H.H. Dale.

  • Barger, George, 1878-1939
Date:
[1911?]
Catalogue details

Licence: Public Domain Mark

Credit: beta-Iminazolylethylamine : a depressor constituent of intestinal mucosa / by G. Barger and H.H. Dale. Source: Wellcome Collection.

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    [.Reprinted from the Journal oj Physiology, Vol. XLI. No. 6, January, 1911.] /9-I MIN AZOLYLETHYL AMINE A DEPRESSOR CON¬ STITUENT OF INTESTINAL MUCOSA. By G. BARGER and H. H. DALE. (From the Wellcome Physiological Research Laboratories.) The description of a symptom-complex common to the action of commercial “ peptone ” and of extracts of certain organs, such as intestine, brain, thyroid gland, etc. has formed the subject of numerous papers by Popielski and his co-workers1. Lohmann2and von Furth and Schwarz3 have identified choline as a depressor constituent of such extracts, but, as Popielski and his followers have made clear, the very marked depressant action of these extracts cannot be entirely due to choline, whatever be the final outcome of the discussion as to whether pure choline is depressant. The effects attributed by Popielski to the hypothetical “ vaso-dilatin ” include fall of blood-pressure, due to vaso-dilatation ; loss of coagulability of the blood; violent peristalsis, contraction of the bladder; accelerated secretion of saliva, pancreatic juice and, to a less extent, of bile; depression and narcosis. He regards as fundamental effects the fall of blood-pressure, due to “ paralysis of the peripheral vasomotor apparatus,” and the abolition of the coagu¬ lability of the blood, the other effects being secondary to these. He identifies the Kt secretin ” of Bayliss and Starling with “ vaso-dilatin,” so that the action of secretin on pancreatic secretion is, according to his view, a secondary and non-specific effect. Though the repeated association of certain actions is suggestive, it by no means amounts to a proof that they are all produced by a single chemical substance. One of us recently, in conjunction with 1 Popielski. Pfliiger's Archiv, cxxvm. p. 191. 1909. Modrakowski. Ibid, cxxxm. p. 291. 1910. 2 Ref. Zentralbl. f. Physiol, xxn. p. 616. 1908. 3 Pfliiger’s Archiv, cxxm. p. 361. 1908. PH. XLI. 33