The bile-salts (glyco- and tauro-cholate of soda) in their relation to the secretion of urea, &c. / by G.H. Edington.

  • Edington, George Henry.
Date:
[1896]
Catalogue details

Licence: Public Domain Mark

Credit: The bile-salts (glyco- and tauro-cholate of soda) in their relation to the secretion of urea, &c. / by G.H. Edington. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    ing exhibition of medicine regularly. It was necessary to change the dressings on the fistula frequently, on account of their being saturated with discharge of bile. The faeces, however, were always normally coloured, although somewhat offensive. On one occasion the fistula was tightly plugged with gauze, and this was left in for twenty-four hours at least, without any accumulation of bile having taken place in the gall-bladder. The patency of the ducts having been established beyond doubt, it was decided to close the fistula. This was done by inverting the rawed edges of gall-bladder and stitching the freshened skin-margin over that viscus. The wound healed by first intention and the patient went cut well. A month or so later she reported herself as having kept well since dismissal. II. Limitation of the Inquiry. Towards the end of May, Dr. Fleming suggested to me the advisability of utilising the opportunity thus presented of analysing fresh human bile, and on the 6th of June the collect- ing of the discharge from the fistula was commenced. It was at first intended to make a complete analysis of the secretion, but it was found that this would involve more time than was available, and on talking the matter over with Professor M'Kendrick it was finally resolved to limit the inquiry to the determination of the bile-salts (Glycocholate and Taurocholate of Soda), the influence, if any, on the quantity secreted, of diet, time during the twenty-four hours, and temperature, and also as to any relation between the excretion of the salts and the amount of the urea excreted in the urine. It was also determined to note the quantity of bile collected four-hourly, it being kept fully in mind, however, that there was a free vent into the intestine which would hinder any conclusions being drawn as to the total quantity excreted in the twenty-four hours. III. Methods. An attempt was made to collect the bile in the way described by Noel Paton (1), by means of an india-rubber tube connected with a Woulfs bottle; but this not proving successful, a modification vol. xxx. (n.s. vol. x.) p
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