Some observations on the antiseptic and physiological action of resorcin / by W.B. Platt.
- Platt, Walter Brewster, 1853-1922.
- Date:
- 1883
Licence: Public Domain Mark
Credit: Some observations on the antiseptic and physiological action of resorcin / by W.B. Platt. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![nwvcnipiit of foro-logs. Up to G.36 nearly same with oeeasioiial short intermis- sions. i).3U. Stnu'jxles further, a violent sj)asm, head drawn baek at right antrles to body, intermittent jerking of limbs. G.42. Temperature very high, doii does not notiee objeets plaeed close to head Erection of ])cnis. G.54. ^lovements almost none. G.57. jMovements almost none, confined almost en- tirely to fore-less. 7.02. No movement of limbs. Kespiration 144 per minute; gas|is. 7.08. Running movements recommence with fore-paws for a few seconds. 7.22. Dog appears almost normal, with slightly ra])id respiration. Still does notice noisi's or objects; greatly e.xhaustcd. iVnimal nmo left. 12M at G A. M.—Animal found dead, after at least 2G hours. Autopsy.—April 12, at 11 A. M. Shows right side of heart gi-eatly distended with blood. Left firmly contracted, endocardium stained red. In right auricle a firm <rray-yellow filirinous adherent clot. In lungs wedge-shaped infarctions. Stomach.—Near pylorus, staining red of mucous membrane, large amount of mu- cus in stomach. Bladder contained about 5 c. c. of greenish, turbid, faintly alka- line, highly albuminous urine, containing many spermatozoa, a number of epi- thelial and coarsely granular casts and leucocytes. Many oil globules. Brain and cord show nothing abnormal, macroscopieally, except distension of cerebral vessels. Liver, spleen, and kidneys nearly normal. Expt. 4. May 2 —Black and tan male dog, weight 5G10 grammes, receives 2 grammes of resorcin in 8 e. c. water hypodermically at 5.1.5 B. M. 5.17. Un- ea.sy, trembles, vomits frequently. 5.23. Fell over when trying to stand. 5.25. Twitching begins (of limbs). 5.29. Lifts up right front paw often. 5.39. Snaps with jaws frequently. 5.58. Can stand; twitching continues ; conscious and intelligent. The snapping and twitching continued until at least 8.00 P. M. Dog apparently well next day from two grammes of resorcin. ICxpt. No. 5.—April 5, ’82, 3.55 P. AI. A full-grown rabbit, male, weight 1935 grammes, injecteil hypodermically with 0.500 grammes resorcin at 4.54 P. M. 4.57^. Movements of fore-paw. 5. Movements of fore-paw continued. 5.08. Very rapid respiration. 5.21. Can stand up on hind-legs. 5.35. With excejition of a few twitchings runs well and now normal. None the worse for di- gram me of resorcin after 41 minutes. Expt. No. G.—April 13, 4 17 P. M. A female white albino rabbit, weighing 1915 grammes, injected beneath skin of abdomen with 1 gramme of resorcin dissolved in 2 c. c. distilled water. Injected in 3 places. 4.19. Very rapid res- piration. 4.25. Some twitchings of limbs, also of neck muscles. 4.27. Some twitchings of abdominal muscles. 4.29. Ears twitch together; trembles. 4.30. Constant and rapid twitchings of legs. 4.38. All symptoms increase. 4.40. Staggers, nearly falls. 4.48. Constant twitching of tail. 4.53. Fore-legs kept extended as rabbit squats down ; constant twitching of hind limbs. 5.04. Rio-ht hind-leg twitches 40 to a minute. 5.10. Twitchings almost stopped; respira- tions lower and shallower. 5.13^. Death after 56^ minutes from 1 gramme resorcin. Summary—Of four dogs, apparently healthy, 2 grammes were fatal to one female poodle weighing 4310 grammes (in proportion 1 to 21.55), after 1 hour and 49 minutes, but not fatal to a small terrier, wei^hino- 5610 grammes (proportion of 1 to 2(S05). Symptoms continuing at least three and not more than 17 hours. 1^ grammes killed a dog, male ter- rier, weighing 4675 grammes (proportion 1 to 3116.6), after 26 hours and within 37 hours. One gramme was not fatal to a female terrier weighing 4517 grammes (proportion 1 to 4517), the symptoms pa.ssing off mostly in half an hour. Of two rabbits, 1 gramme caused death in 56^ minutes in a female albino weighing 1915 grammes ([iro|)ortion 1 to 1915). One-halt gramme did not cause death in a full-groAvn male, wei'diiii](https://iiif.wellcomecollection.org/image/b22332510_0017.jp2/full/800%2C/0/default.jpg)
