On metabolism in phthisis / by Francis W. Goodbody, Noel D. Bardswell and J.E. Chapman.

Date:
1902
Catalogue details

Licence: In copyright

Credit: On metabolism in phthisis / by Francis W. Goodbody, Noel D. Bardswell and J.E. Chapman. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    figures given in the tables represent tlie absolute quan- tity of the diet coustituents taken, the amount ordered bein^- only occasionally eaten. In Periods B, 0, and D a weighed quantity of figs and grapes was given, as some of the patients suffered considerably from consti- pation, and, as will be noticed later, in some of the cases it was necessai-y to give enemata. (It was decided to take this means of evacuating the large intestine, as it appears to cause as little interference with metabolism as the administration of drugs.) The total nitrogen was estimated by KjeldahFs method, no further oxidising agent being employed in the case of the urine, while sodium pyrophosphate was added for the purpose of estimating the oxidation of the faeces. The quantity of ui-ea was estimated by the sodium hypobromite method. The method of Gowland Hopkins was used for estima- tion of the uric acid, ammonia being added to hasten the conversion of this substance into ammonium biurate. Schlosing^s apparatus was employed for the estimation of the quantity of ammonia. The amount of phosphoric acid was estimated by the uranium nitrate method, and that of the chlorides by precipitating with silver nitrate, and then titrating with potassium sulphocyanide. The quantity of sulphates in the urine was estimated by Baumann^s method—that is, precipitated with barium chloride, and weighing the barium sulphate thus obtained. The estimation of the quantity of fats in the faeces was made by extraction of the px-eviously acidified dried fasces with ether in Soxhletb's apparatus, the ether extract being dried at 100° C, and weighed after cooling over sulphuric acid. Two analyses were made in each case, and the average taken, except in the analysis of the sulphates. In the following description the successive periods are lettered A, B, C, D. Approximate Diets.—The following can be taken as
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