I. On the lymphatics in leprosy. II. On the changes in the sweat-glands in cancer and leprosy. III. On the growth of the fungi in ringworm, favus and trichorexis nodosa / by George Hoggan.
- Hoggan, George
- Date:
- 1879
Licence: Public Domain Mark
Credit: I. On the lymphatics in leprosy. II. On the changes in the sweat-glands in cancer and leprosy. III. On the growth of the fungi in ringworm, favus and trichorexis nodosa / by George Hoggan. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
19/34 (page 17)
![that in no case whatever have I found that the gland-duct dia appeared at its peripheral end in the early part of the degeneration. The first point of interest we have to observe in the gland just referred to is the peculiar distortion that ‘it has begun to undergo, and which is evidently due principally to the great deposition of leprous cells around it. There is nothing specially unusual in the fact that a gland duct may become spiral near its termination, even before it enters the epidermis, where, of course, the spiral is the rule for very obvious causes. In the present case, the spiral is probably increased by the manner in which the deposit of leprous cells take place. In a former paper, I showed that this deposit takes place specially in the plane or zone of the vascular plexus, thus leaving a certain amount of gelatinous or white fibrous tissue between that zone and the lower surface of the epidermis. This layer of gelatine finally disappears, or is absorbed, and, consequently, that portion of the sweat-duct which formerly stretched across it, is forced to accommodate itself, in its absence, by assuming the spiral form, upon the same principle that it assumes the spiral in the epidermis. The preceding change is, however, unimportant compared with what takes place at the glomerulus. There it will be observed that the globular form of this, the secreting portion, of the gland, is being gradually destroyed; partly, apparently, by lateral pressure from the neighbouring tissues upon it, but principally and primarily through pressure from above downwards, owing to which the glome- rulus is becoming elongated, and its tubular coil is becoming unwound or unravelled. This, I think, is evidently due to the deposition of the thick layer of leprous cells above the glomerulus, which, reacting upon the gelatinous tissue surrounding the glomerulus, pushes it down- wards, forcing it to uncoil at the same time, a change which is very manifest when compared with the globular form of the glomerulus of the gland to the right, which is as yet but little affected. This elongating or uncoiling of the glomerulus is, I may state, the genera] rule throughout the degenerating glands. Contemporaneously with the distortion of the glomerulus, but whether caused by it or not I cannot say, we have much more important changes going on in the structure of, and in the cells lining, the gland tubules. Even by the low power at which that gland is represented, it is easy to observe that the lumen of the glome- rulus portion of the tubule is becoming much more dilated than that of the excretory duct. We may also observe that the lower portion 2](https://iiif.wellcomecollection.org/image/b22354980_0021.jp2/full/800%2C/0/default.jpg)
