The prescribing of proprietaries, especially proprietary mixtures / Solomon Solis-Cohen.

  • Solis-Cohen, Solomon, 1857-1948.
Date:
1908
Catalogue details

Licence: In copyright

Credit: The prescribing of proprietaries, especially proprietary mixtures / Solomon Solis-Cohen. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    3. A brief statement of the pharmaceutic necessities of the particular mixture, as a guide to the proportion- ing of doses. For example, let me take the formula of a prepara- tion not in the Pharmacopeia or X. F., which I Hve employed very much in rheumatic cases during many years, and have repeatedly published. It is known in the house pharmacopeias of the Jefferson Medical Col- lege Hospital, the Philadelphia Polyclinic Hospital and the Philadelphia General Hospital as Mistura ferri salicylata (Salicylated iron mixture). A standard mixture is dispensed under this title which contains 0.5 gm. of natural sodium salicylate and 0.5 c.c. of tincture of ferric chloric! to the teaspoonful, estimated at 4 c.c. Sometimes in prescribing it one wishes to in- crease or to diminish the iron relatively to the sodium salicylate, or vice versa. We know that this can easily be done within a range of 30 per cent. In order to prevent the precipitation of iron salicylate, two pharma- ceutic expedients are necessary—the use of a slightly acid ammonium citrate solution in the vehicle (approx- imately half, i. e., 2 c.c. in the 4 c.c. dose), and the addi- tion of the iron last, drop by drop, with continuous stir- ring, up to the required quantity. To permit any consid- erable increase in the iron there must be proportional in- crease in the citric acid content. It is also better made when a few drops of glycerin are used in each do*e, and it can be flavored appropriately with a natural methyl salicylate. The standard formula is the result of ex- periment as to the best pharmaceutic proportions, and in this the active ingredients are as stated, with suitable quantities of glycerin, solution of ammonium citrate and oil of birch or oil of wintergreen. When no other direction is given this is dispensed. It can be varied in two ways. 1. The best way is to write the quantities of active ingredients in full, and of the vehicles, flavor, etc., in blank, or with a q. .s. Thus: It- Sodium salicylate (true) Tincture of ferric chlorid Oil of wintergreen Glycerin Citric acid Solution of ammonium citrate gm. or c.c. 2120 •: (q-s-) | . (q.s.) ] or . . (q. s.) (B. P.) | q. s. ad 321 gr. xxx m. xxxvi flSi