The theory and practice of anti-rabic immunisation / by Captain W.F. Harvey and Captain Anderson McKendrick ; issued under the authority of the Government of India by the Sanitary Commissioner with the Government of India, Simla.

  • Harvey, W. F. (William Frederic)
Date:
1907
Catalogue details

Licence: In copyright

Credit: The theory and practice of anti-rabic immunisation / by Captain W.F. Harvey and Captain Anderson McKendrick ; issued under the authority of the Government of India by the Sanitary Commissioner with the Government of India, Simla. Source: Wellcome Collection.

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    Limit reached—nil. M. I. D, not greater than o'2 cc. of a 40oo-fold dilution. (3) Two-day cord— Number of experiments 7. Dose o*2 cc. i. Dilutions ; ~~ ; 2^0 ; 6 experiments. In all cases paresis by the 6th or 7th day. ii. Dilution ; 1 experiment. Paresis after 34 days. Limit—0*2 cc. of a i,ooo-fold dilution. (4) Three-day cord— Number of experiments 12. Dose o'2 cc. i. Dilutions ~ ; 8 experiments. In all cases •paresis by the 6th or 7th day. ii. Dilutions ; 4 experiments. Paresis in 6 to 13 days. Limit—o'2 cc. of a 200-fold dilution. (5) Five-day cord— Number of experiments 10. Dose 0*2c.c. i. Dilutions —■ • ; 8 experiments. In all cases paresis by the 6th or 7th day. ii. Dilution ; 2 experiments. Paresis doubtful ; certainly well over the limit of 6 or 7 days. Deaths after 23 and 33 days. Limit—0*2 cc. of a ioo-fold dilution. (6) Nine-day cord— Number of experiments 3. Dose o*2 cc. Dilutions — and ~ • IO 5 Result—no rabies ; progressive emaciation ; death. Limit (if any)—some concentration greater than is represented by o’2 cc. of a 5-fold dilution. The M. I. D’s obtained with fresh, three-day, five-day, and nine-day dried material give us four well separated points on a curve convex to axes representing respectively the degree of dilution of the material used and the time of desiccation undergone. This number of points, well interspaced as they are, is sufficient to enable the curve to be plotted with fair accuracy. We have, however, as described in the text, also carried out a certain number of experi-
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