The mechanism of histamine release / W.D.M. Paton.

  • William Paton
Date:
[1956?]
Catalogue details

Licence: In copyright

Credit: The mechanism of histamine release / W.D.M. Paton. Source: Wellcome Collection.

    12/20 page 68
    complete in one hour, but octylamine a slower, less intense, more prolonged one, sometimes still developing after four hours. (3) I have recently done some experiments comparing the two on perfused skin with respect to whether or not they release potassium (Fig. 6). With compound 48/80, you can get NORMAL TYRODE POTASSIUM FREE TYRODE 48/80 !0 O 10 20 30 40 50 60 70 90 OO w©0 MO 120 '30 to * o so H 2-0 • o o octylamine (DM 0 (6 20 30 40 50 60 70 90 70 'OO MO Ash’ 1 *70 K* **5 wo JT 20 H i o o 25 20 5 IO 5 OCTYLAMINE I M f n. T k\ J*- O >0 20'30 40 50 O 'O 20 30 40 50 9© 70 80 70 IOO Fig. 6. Experiments on histamine (H) and potassium (K+) release in cat’s isolated skin preparation perfused with normal Tyrode (left-hand graphs) or potassium-free Tyrode (right-hand graphs). Injections into artery of compound 48/80 (upper graphs) or octylamine (lower graphs). a good histamine release without any change in the potassium flowing from skin, whether perfused with potassium-free solution or with potassium in a concentration normal for Tyrode solution. With octylamine on the other hand there is a distinct potassium release, in magnitude something like five or ten times the amount of histamine release in terms of potassium ion and histamine base. The interpretation of this is not clear but it both supports the general view that there
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