The Medical and scientific archives of the Adelaide Hospital. No. 3.
- Adelaide Hospital (Adelaide, S. Aust.)
- Date:
- [1924]
Licence: Public Domain Mark
Credit: The Medical and scientific archives of the Adelaide Hospital. No. 3. Source: Wellcome Collection.
36/58 page 32
![EXAMINATIONS ON THE SERUM OF CASES RESEMBLING TYPHUS FEVER (BRILL’S DISEASE). (By Dr. L. B. Bull, Deputy Director of the Laboratory.) The Weil-Felix reaction has been performed 27 times on 16 cases of patients suffering from this disease. A positive reaction was obtained in the course of each case. A summary of the results is given in the accompanying table. Eight of the cases were under the care of private practitioners. As a control the test has been performed on 61 patients suffering from other diseases. Sixteen of these sera gave a positive Widal reaction. In every case the Weil-Felix test gave a negative result. In five cases only was there any degree of agglutination with sedimen¬ tation, and in these it was never more than a slight sedimentation in a dilution of 1 in 40. An agglutination with sedimentation in a dilution of 1 in 40, with partial sedimentation in higher dilutions, is taken to represent a positive reaction. The effect of heating the serum has been tested on 13 sera giving a positive reaction. The sera have been heated to 56° C. and 65° C. respectively for half an hour, and retested. In all cases heating the serum to 65° C. for half an hour has completely destroyed the agglutinating power of the serum. A few of the sera have become solidified when heated to this temperature, probably as a result of a high globulin content. Heating to 56° C. does not completely destroy the agglutinating power of the serum, but in most cases it has reduced this power ; e.g., a serum giving a complete agglutination in a dilution of 1 in 10,240, after being heated to 56° C. showed a zone of inhibition in dilutions up to 1 in 80, and complete agglutination in dilutions no higher than 1 in 2,560. Weil-Felix Reactions, 1923. 1 ■ I Patient, j Sex. 1 i Age. 1 1 Days Ill. 1 Pyrexia. Weil-Felix Reaction. t K. A. .. M. | : 38 I About 10 i 4 C. 1 in 160. P. 1 in 320. i ' j ! 16 C. 1 in 640. P. 1 in 2,560. L. W... F ! 50 15 4- C. 1 in 80. A. C. 1 in 160 1 About 20 C. 1 in 160. P. 1 in 320 1,. G.... 1 M. 17 15 None C. 1 in 640. P. 1 in 1,280 . ; ! 23 None C. 1 in 320. P. 1 in 640, 1 and P. 1 in 1,280 W. B. . M. 38 About 19 4 C. 1 in 320. T. 1 in 640 ] 25 to 32 None C. 1 in 640. A. C. 1 in 1,280 P. 1 in 2,560 A. I,.... M. 24 14 99° C. 1 in 640. P. 1 in 1,280 1 20 None C. 1 in 1,280. P. 1 in 2,560 H. W. . | M. 17 S 4 C. 1 in 40. P. 1 in 80 H None C. 1 in 320. A. C. 1 in 640 J 24 None ! C. 1 in 40. A. C. 1 in 80. • ij. 1 ■ Lx P. 1 in 640 W. J. . M. i 1 - l C. 1 in 320 1 (C. = Complete agglutination. A.C. == Almost complete agglutina¬ tion. P. = Partial agglutination.)](https://iiif.wellcomecollection.org/image/b32156789_0036.jp2/full/800%2C/0/default.jpg)
