On the modifications of the metabolism produced by the administration of diphtheria toxine / by D. Noel Paton ... [and others].

Date:
[1899]
Catalogue details

Licence: Public Domain Mark

Credit: On the modifications of the metabolism produced by the administration of diphtheria toxine / by D. Noel Paton ... [and others]. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

    24/30 (page 354)
    Very similar results were obtained by Salkowski, although in his paper1 he does not consider the excretion of chlorine in relationship to the excretion of the alkalis. But we find two cases in which the excretion of chlorides was studied and we here reproduce his figures, converting the NaCl into Cl. From pp. 218 and 225. K Na K + Na Cl Temperature 24 3-044 0-354 3-398 1-085 25 2-301 0-311 2-612 1-221 26 1-701 0-226 1-927 1-241 - 27 2-629 0-521 3-150 1-524 36° to 40° C 28 2-438 0-518 2-956 1-599 29 1-906 0-360 2-266 1-566 30 0-862 0-625 1-487 1-417 36° C. 31 1-032 3-984 5-016 7-87 ] - below 36° C. 1 2-905 7-540 10-645 16-08 j om pp. 21 224 and 225. 3-44 0-77 4-21 1-45 above 40° C. 24 0-520 2-934 3-454 5-106 between 25 0-728 4-334 5-062 8-74 ’ 36 & 37° C. 26 2-260 6-431 8-691 15-58 ] - below 36° C. 27 1-528 3*206 4-734 9-24 j The meaning of this condition is not easy of explanation. It may indicate a retention of chlorine as some halogen compound of the proteids, but our investigations throw no light upon this question. Nor do they elucidate the problem of what acids take the place of hydrochloric acid in combining with the alkalis in the urine. It is known that in fever lactic acid and other organic acids appear in the blood and it is possible that these may replace the chlorine. Conclusions. Under the influence of diphtheria toxine in the dog— There is no interference with the digestion and absorption of proteids. There is a marked increase in the proteid katabolism, probably as a result of a direct toxic action on the protoplasm. There is an interference with the elaboration of waste nitrogen into urea which leads to an increase in the proportion of nitrogen not as urea in the urine. No marked increase in the proportion of nitrogen in ammonia occurs. 1 Virchow's Arch. liii. 1871.