On the modifications of the metabolism produced by the administration of diphtheria toxine / by D. Noel Paton ... [and others].

Date:
[1899]
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Licence: Public Domain Mark

Credit: On the modifications of the metabolism produced by the administration of diphtheria toxine / by D. Noel Paton ... [and others]. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    [Reprinted from the Journal of Physiology. Vol. XXIV. No. 5, July, 1899.] ON THE MODIFICATIONS OF THE METABOLISM PRODUCED BY THE ADMINISTRATION OF DIPH- THERIA TOXINE. By D. NOEL PATON, M.D., F.R.C.P. Ed., B.Sc., JAMES CRAUFURD DUNLOP, M.D., F.R.C.P. Ed., and IVISON MACADAM, F.R.S.E. (One Figure in Text.) {From the Research Laboratory of the Royal College of Physicians, Edinburgh.) I. Preliminary. It is now almost universally admitted that a high temperature is not an essential part of infective febrile processes, but that it, like the other symptoms, is one of the results of the toxic action of the products of micro-organisms, and that it is caused in the first instance by diminished heat elimination. In the later stages of some fevers increased heat production undoubtedly plays a part. A vast number of observations on the influence of these infective processes on the economy have been recorded, but a study of such a work as von No or den’s Pathologie des Stoffwechsels, shows how much yet remains to be investigated before we can comprehend the modifications in the chemical processes in the body induced by these conditions. In attempting to gain a knowledge of such changes we have to depend largely on the study of the alterations in the excretions—in the expired air and in the urine. So far the study of the respired air has yielded more constant and conclusive results than the examination of the urine. For in the case of the latter excretion, when we come to compare the many different observations which have been recorded, the discrepancies which manifest themselves are so evident that it is difficult to draw any satisfactory conclusions. It appeared to us that a careful and systematic study of the effect ph. xxiv. 23