"Salvarsan" or "606" (dioxy-diamino-arsenobenzol) : its chemistry, pharmacy and therapeutics / by W. Harrison Martindale and W. Wynn Westcott.

  • Martindale, W. Harrison (William Harrison), 1874-1933
Date:
1911
Catalogue details

Licence: In copyright

Credit: "Salvarsan" or "606" (dioxy-diamino-arsenobenzol) : its chemistry, pharmacy and therapeutics / by W. Harrison Martindale and W. Wynn Westcott. Source: Wellcome Collection.

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    do not get the opportunity to recover before they are exposed to subsequent fresh infection. Alt satisfied himself as to the value of this surmise by experimenting on dogs. McDonagh (102) has given a review of this initial work of Ehrlich’s. He states the best results in vivo with ‘ 606 ’ are obtained when the spirillar disease is at its height; the body is saturated with the specific organisms which produce anti- bodies, and obviously the more organisms the more antibody. A. Lesser (105) provides a recent somewhat critical survey of Ehrlich’s principle. He states that there is no exact proof of a direct parasitotropic action of ‘606’ in the human organism. The claim that this is so is based, Lesser points out, on analogy with results of treating spirillosis in fowls and trypanosome infection in mice. Whether the action is spirillo- tropic or organotropic, ‘606’ is, according to Lesser, the most powerful antisyphilitic so far in use. RESULTS. We have arranged the results approximately in the following order:— Primary and secondary cases of syphilis. Tertiary syphilis and reports on varied forms. Hereditary cases. Parasyphilitic cases. Complications. Primary and Secondary Syphilis. Alt (1) states primary syphilitic sores were reduced in a few days by the administration of ‘ 606.’ Indurating action was also reduced; maculo-papular eruptions of a moist ulcerating character were reduced in colour and dried up. Ulcerations on the genital labia healed in a few days; large papules on the back and side in most obstinate cases were cured, specific angina diminished—in short, the substance ‘ 606 ’ was specific in its action with one injection. Wechselmann (ia) first exhibited syphilitic patients who had been cured by ‘ 606 ’ at the Berlin Medical Society, June 22, 1910. He was especially enthusiastic regarding cases of
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