Working bulletin for the scientific investigation of Cascara sagrada (Rhamnus purshianus) / issued in pursuance of a system of collective investigation of new drugs established and conducted by the Scientific Department of Parke, Davis & Co. ; analytical chemistry under charge of A.B. Lyons, pharmacology under charge of F.E. Stewart, botany H.H. Rusby.

  • Parke-Davis
Date:
1885
Catalogue details

Licence: Public Domain Mark

Credit: Working bulletin for the scientific investigation of Cascara sagrada (Rhamnus purshianus) / issued in pursuance of a system of collective investigation of new drugs established and conducted by the Scientific Department of Parke, Davis & Co. ; analytical chemistry under charge of A.B. Lyons, pharmacology under charge of F.E. Stewart, botany H.H. Rusby. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    business engagements, frequently causing heavy pecuniary loss Examination during pLoxysms g!vf temperature*norm'aJ, surface of body cool, abnormal sensitiveness to hght and sound. Inorexia and nausea, with a history of inveterate constipation of the bowels. The sclerotic and orbital region showed a well marked icteric tint. Placed patient upon rhamnus purshiana. and succeeded in producing one evacuation per day. No paroxysms in February, March, April, and May. A slight attack in June, attributed by patient to failure to take the medicine. . . , t Oct I No attack since June; taking one-half the amount required last January. Nov 23 Called for medicine. Had taken none for five weeks; feared an attack. Jan I 1880 No violent attack since first dose of medicine. Patient satisfied he has found a specific, and a goodly sized Christmas box delivered at my office marks his appreciatmn. ^ hysterico-hypochondriacal female, with history of uterine trouble, and gynecological investigations. Said she believed if she could procure a free evacuation from the bowels once per day, the exciting cause or most of her affections would be removed. May 3. Acting upon her suggestion as to an evacuation each day, I put her upon a mixture of: If, Ext. rahmni pursh. fl., 5 j. Ext. belladonnae fl., 3]. Tr. nucis vomicae, 2 ij. Syrupi et aquae, SS ad. | iv. Sig.—Teaspoonful thrice daily. At first medicine produced slight catharsis. Reduced dose to teaspoonful twice a day, and on June 20 to one teaspoonful each morning at 10 a.m., she claiming this sufficient to produce the necessary evacuation. Dec. 10. She informs me that she has not been better in ten years. Taking one tea- spoonful per day. Case 3.—Clinic Michigan College of Medicine: E. F., female, aet. 21. complained of hemorrhoids dating from the period of gestation some 18 months since. Had been treated for more than a year with slight temporary relief. A well-marked case of portal congestion with history of dyspepsia and chronic con- stipation. I directed 15 drops of the extract to be taken three times per day for one month, at the end of which time she reported entirely cured. Have administered it to a number of cases at my clinic during the past three months, and the record shows that in no case where patients have reported have the effects failed to be beneficial. Report 38 *—Mrs. B., set. 62. Was called to see her March 6th. Found patient much emaciated and low-spirited, having been in the hands of several practitioners without obtaining any benefit. Her last physician, a homoeopath, had diagnosed inflammation of stomach, gave little pills, and ordered diet of cabbage and boiled onions to the exclusion of almost everything else. In getting the history of the case, I found that it began with obstinate constipation, about six months ago. The constipation was a more or less promi- nent symptom throughout her illness. I found great flatulent distention of stomach, the greater curvature reaching to within 2}4 inches of the pubis. There was considerable tender- ness of abdomen, and fsecal accumulation in ascending colon. The tongue was heavily coated, breath foul, temperature normal, pulse 76, weak and compressible. She complained much of heat and burning in her throat, and eructations of gas from her stomach, and often vomited her food (cabbage and onions). Besides she had much palpitation of the heart and fullness in chest, and, as she said, ball in her throat the size of a goose egg. Her bowels had not moved in eleven days; she was very apprehensive, declaring she was going to die anyway. Looking the case over very carefully, I concluded that the whole difficulty depended upon the condition of the bowels, and giving a favorable prognosis, ordered large injections and a tablespoonful of the following every four hours until the bowels should move: B Sodii bicarb., 4.00. Pulv. rhei., 16.00. Spts. menthae pip., 8.00. Syr. rhei. arom., q. s. ad., 125.00. M. Ft. sol. *Dr. Med. Karl V. Ruck, Norwalk, Ohio, in Therapeutic Gazette, 1880; p. 259.