Collected papers (Part I.) from the Research Laboratories of the Royal College of Physicians, London, and the Royal College of Surgeons, England / edited by T.G. Brodie.

Date:
1903
Catalogue details

Licence: In copyright

Credit: Collected papers (Part I.) from the Research Laboratories of the Royal College of Physicians, London, and the Royal College of Surgeons, England / edited by T.G. Brodie. Source: Wellcome Collection.

    16/462 (page 4)
    Half an hour after the injection of 2 5 per kilo of dextrose, the . sugar contents of the blood were found to be normal, but after another half hour the amount was decidedly greater (mean of 5 expers., 1'85 per 1000). No explanation of this can be suggested. Urine.—The sugar makes its way extremely rapidly into the urine, as much as 4'5 per cent, of the saccharose injected finding its way out within 1-^ minutes. The percentage excreted within one hour of the injection of 1 grm. per kilo was :— Saccharose Maltose Lactose Galactose Laevulose Dextrose 81-0 56-5 48-7 28-9 20-9 15-6 The figures obtained in different experiments with the di- saccharids do not deviate much from the mean, whereas with the monosaccharids the deviation in individual experiments is very great. The urine secreted during one hour succeeding an injection of 0 25 grm. per kilo of dextrose was examined in 5 cases, and the mean sugar content is just double that of the 16 normal urines tabulated in the early part of the communication. Saccharose, lactose, galactose and laevulose appear to be excreted unaltered, while maltose (from the K and opticity found) seems to be to some extent hydrolysed, and dextrose gives evidence of more or less dehydrolysation having occurred. Glycogen. Glycogen was injected only in 10 per cent, solution. The blood was found one hour afterwards to contain a mixture of carbo- hydrates soluble in alcohol with conspicuously low CuO reducing power. The urine, which was always tinged with haemoglobin and contained albumin, contained besides sugar, a considerable quantity of achroodextrins. Subcutaneous Injection, Thirty experiments were made on rabbits, using the same series of sugars as was used for intravenous injection. The sugar, 1 grm. per kilo in 10 per cent, solution, was injected from a burette into the subcutaneous tissue of the back. Blood and urine were examined