Licence: In copyright
Credit: The plant alkaloids / by Thomas Anderson Henry. Source: Wellcome Collection.
Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.
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![that of conhydrine separating first from alcohol. The base has be> n re-examined recently by Lbltler/ and many of the data previously recorded regarding it shown to be inaccurate. It crystallises from dry ether in slender needles, m.p. 105°-10G°, b.p. 236°-236-5°, [a]j, + 10-98° to + 11 -06°, or from wet ether in plates, m.p. 80° {approx.), and is a strongly alkaline base. The hydrochloride, m.p. 212°-213°, crystallises from alcohol; the aurichloride, B.HAUCI4, m.p. 133°- 134°, is not identical with conhydrine aurichloride as was formerly supposed : the platinichloride, m.p. 185°-186°, forms slender golden- yellow needles. ;^-Conhydrine is a hydroxyconiine since on treatment with hydriodic acid it yields iodoconiine, which on reduction yields d-coniine. With phosphoric oxide it yields t/--coniceine, CsHijN {see p. 33). (^-Conhydrine is not stereoisomeric with conhydrine, but according to Loffler probably contains the hydroxyl group in the y-position thus : NH CHa/^^CH.CH.o.CHo.CHs CHas /CH, 2\y _ CHOH ^-Conhydrine (Loffler) but this is difficult to reconcile with Willstatter’s statement ^ that i^-conhydrine, like conhydrine, yields piperidine-2-carboxylic acid on oxidation. y-Coniceine, CgHigN. This base was isolated by Wolffenstein from commercial coniine by the method already described.'^ In using von Braun’s method of separation the y-coniceine on benzoylation passes into benzoyl-4-aminobutyl propyl ketone, COPh.NH.CHg.CHg.CHg.CHa.CO.C3H7, which remains with the benzoylconiine after extraction of the tertiary bases, and can be partly separated from it by concentrating the ethereal solution and pouring into light petroleum, in which it is insoluble. The rest 3 Ibid. 1895, 28, 302.](https://iiif.wellcomecollection.org/image/b2196189x_0043.jp2/full/800%2C/0/default.jpg)
