Skeletal changes affecting the nervous system produced in young dogs by diets deficient in vitamin A / by Edward Mellanby.

  • Mellanby, Edward, Sir, 1884-1955.
Date:
[1941?]
Catalogue details

Licence: In copyright

Credit: Skeletal changes affecting the nervous system produced in young dogs by diets deficient in vitamin A / by Edward Mellanby. Source: Wellcome Collection.

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    REFERENCES Danby, W. E. & Blackfan, K. D. [1914]. Amer. J. Dis. Child. 8, 406. Danby, W. E. [1919], Ann. Burg. 70, 129. Mellanby, E. [1926]. J. Physiol. 61, 24 P. Mellanby, E. [1931]. Brain, 54, 247. Mellanby, E. [1933]. Edinb. Med. J. 40, 197. Mellanby, E. [1934], Nutrition and Disease. Edinburgh and London: Oliver and Boyd. Mellanby, E. [1935]. Brain, 58, 141. Mellanby, E. [1938]. J. Physiol. 94, 380. Mellanby, E. [1939a]. III. Congres Neurologique International, Comptes Rendus, 797. Mellanby, E. [19396]. J. Physiol. 96, 36 P. Moore, L. A., Huffmann, C. F. & Duncan, C. W. [1935]. J. Nutrit. 9, 533. Moore, L. A. [1939]. J. Nutrit. 17, 443. Wittmaack, K. [1926]. Handbuch der speziellen paihologischen Anatomie und Histologie (Berlin), 12, 3. EXPLANATION OF PLATES l-VI Plate I Figs. 2a and 2b. Mesial sections through foramen magnum of +A (a) and -A (b) dogs, to show reduced capacity of cisterna magna in - A dog (26).. Here again the intrusion of the cerebellum into the cisterna magna in 26 is seen. Plate II Figs. 3 a and 36. Coronal sections through 4th ventricles and lateral recesses (foramina of Luschka) of -f A (a) and -A (6) dogs. Note the reduction in size, especially in dorso-ventral diameter of the 4th ventricle (IV), the packed appearance of the choroid plexus and the reduced diameter of the foramina of Luschka (Lu) of the -A dog (36) as compared with the + A dog (3a). Plate III Figs. 4a and 46. Coronal sections through the lateral (Lat.) and 3rd ventricles (III) of + A (a) and -A (6) dogs. Note the distension of these ventricles (internal hydro¬ cephalus) in the -A dog (46) as compared with the normal +A dog (4a). Plate IV Fig. 5 a. Atlas vertebra of dog whose diet contained vitamin A. Note delicacy of outline and large vertebral canal. Fig. 56. Atlas vertebra of dog whose diet was deficient in vitamin A. Note bulbous appearance of all protuberances. Reduction in size of vertebral canal, but overall size of vertebra little affected. Figs. 8a and 86. Cross-sections of femur shafts of +A (a) and - A (6) dogs, (a) Showing nearly normal structure and (6) showing thickened cancellous shaft and great osteoclastic activity. Plate V Figs. 6 a and 66. Transverse sections through the 5th cervical vertebra and the spinal cords of +A (a) and -A (6) dogs. Note the reduction in size of the vertebral canal and the compression of the spinal root ganglion in the - A dog (66) as compared with the + A dog (6 a): also the alteration in shape of the dorsal surface of the intervertebral disc (Int. Disc.) in 66. Plate VI Fig. 7a. Posterior root ganglion (p.r.g.) of dog receiving diet containing vitamin A. Fig. 76. Posterior root ganglion (p.r.g.) of dog receiving diet deficient in vitamin A. Note compression of ganglion between body and lateral processes of vertebrae.