Treatise on Bright's disease of the kidneys : its pathology, diagnosis, and treatment with chapters on the anatomy of the kidney, albuminura and the urinary secretion / by Henry B. Millard.

  • Henry Millard
Date:
1892
Catalogue details

Licence: Public Domain Mark

Credit: Treatise on Bright's disease of the kidneys : its pathology, diagnosis, and treatment with chapters on the anatomy of the kidney, albuminura and the urinary secretion / by Henry B. Millard. Source: Wellcome Collection.

    47/354 (page 21)
    ing specimens indicative of a new formation of epitlielia after the loss of the original epithelial investment. It may be admissible to assume that the enlarged en- dothelial layer serves (at least to some extent) as a substitute for the lost epitlielia. In tubules vv^hose epi- thelia, as in chronic catarrhal nephritis, are transformed into inflammatory or medullary corpuscles, the new- formation also starts from the endothelia. The final result in this instance is known to be the destruction of the tubule and its replacement by newly formed con- nective tissue—a condition which is known by patholo- gists as cirrhosis of the kidney. [Since writing the rough outlines of this article, I have recognized for the first time well-marked endo- thelia in the urine in a case of advanced chronic croup- ous nephritis with fatty degeneration. I found a clus- ter of three or four of these surrounded by free fat granules.] Still more plainly marked are the endothelia in croupous (parenchymatous) nephritis. In fact, the ap- pearances seen in urinary tubules where casts have just formed could not be explained unless by the presence of endothelia. The results of my researches may be summed up in the following statements : 1. The rods discovered by Heidenhain in some varie- ties of the tubuli uriniferi are part and parcel of a retic- ulum present within every epithelium, 2. The reticulum, including its elongated rodlike for- mations, is the living matter proper. 3. The relation of the rods to the rest of the reticulum of an epithelial body varies greatly, the variation prob- ably being due to dilTerent stages or degrees of secretion. 4. The reticulum, including the rodlike formations, in the inflammatory process, both in catarrhal and croupous nephritis, gives rise to a new formation of