Volume 2

Final report of the Royal Commission appointed to inquire into the relations of human and animal tuberculosis.

  • Great Britain. Royal Commission on Tuberculosis
Date:
1911
Catalogue details

Licence: Public Domain Mark

Credit: Final report of the Royal Commission appointed to inquire into the relations of human and animal tuberculosis. Source: Wellcome Collection.

    78/566 (page 76)
    CALF 1371. “3H Dose—100°0 milligrammes. Killed when in good health—May 22, 1908. Clinical Notes. The calf remained well during the experiment. Temperature. On the 10th day after inoculation the temperature rose to 40°2°C., and reached a maximum of 41:0°C. on the 18th day; on the 27th day the temperature fell to normal (39°0° C.) and remained approximately normal subsequently. Tuberculin Test. May 20, 1908. [82 days after inoculation.] Reacted. Rise of temperature, 2°7° C. Weights. ewt. qr. lbs. February 28, 1908 pee ed Ga iat May 22,1908 ... Ty ee Total gain of weight.—25 lbs. Average rate of gain per week.—2 lbs. POST-MORTEM EXAMINATION. The carcass was in good condition. Local Lesion.—At the seat of inoculatien on the left side of the neck there was a prominent fluctuant tumour measuring 10 by 6 by 4 cm.; on section it was a cyst with caseo-puruient contents and fibrous wall lined internally with granulation tissue. Left Prescapular Gland.—The left prescapular gland measured 5:5 by 2°8 by 1:8 cm.; between a third and a half of the gland substance was replaced by a dense yellow caseous gritty mass. Right Prescapular Gland.—The right prescapular gland measured 5 by 2°3 by 1 cm. It was oedematous (recent tuberculin test), otherwise normal, Prepectoral Glands.—Normal., Cervical Gilands.—One on the left side under the first rib had a small calcareous patch in the cortex ; the rest were normal, Thora. Pleura and Heart.—Normal. Lungs.—Just under the pleura of the right lung eight tubercles were seen and there were six counted under that of the left ; they ranged in size up to a millet seed ; the larger ones had opaque yellow centres and one of the small grey ones had a calcareous centre. No tubercles were seen on section. Thoracic Glands.—There were altogether four yellow caseous foci in the bronchial and mediastinal glands. Abdomen. Omentum and Peritoneum ; Spleen.—Normal. Liver.—In the substance of the liver there was a moderate number of grey, sometimes yellowish grey foci, two to three millimetres in diameter ; in places they occurred in groups ; they did not appear to be of a tuberculous nature. Portal Glands.—Normal. Kidneys.—On the surface of the left kidney there were about half a dozen grey foci, the largest 1 mm. in diameter ; on section two of the larger ones were definite tubercles, and each had a minute caseous centre; most of the others extended through the cortex as fine grey streaks. In the cortex of the right kidney there were a few grey streaks seen on the surface as grey points. Suprarenal Bodies—The right was normal. Jeft showed in the cortex a minute yellow focus. Renal Gland.—Normal. Coeliac Gilands.—One the size of a pea was yellow and softened in the centre and had a thick fibrous margin. Lumbar Glands.—There was a minute yellow point in the cortex of one lumbar gland. The Alimentary Tract. Tongue, Pharyna, Tonsils; Submaaillary, Retro- pharyngeal, and Parotideal Glands.—Normal. Intestines—In the small intestine all the Peyer’s patches contained discrete yellow foci, the largest 1 mm. or a little more in diameter ; they were very numerous in the long patch, while the smaller patches contained a moderate number only. The large intestine was normal. Mesenteric Glands.—Those at the extremity of the mesentery contained a number of small yellow gritty tubercles ; the rest were normal or contained one or two small tubercles. Lleo-Colic Glands.—The ileo-colic glands contained a moderate number of calcareous tubercles forming small patches. Testes.—Normal. Various Lymphatic Glands. Axillary, Precrural, Gluteal, Pudic.—Normal. Popliteal.—The left contained five, the right four, yellow caseous and slightly gritty tubercles, the largest a little more than 1 mm. in diameter. Ischiatic.—One contained a caseous tubercle the size of a millet seed. Microscopical Examination. Tubercle from Kidney.—Four tubercle bacilli seen. Foci from Liver.—No tubercle bacilli. Yellow Foci from Small Intestine examined).—No tubercle bacilli. Smear from Coeliac Gland.—No tubercle bacilli. Tubercle from Popliteal Gland.—A moderate number of tubercle bacilli seen. (two . films