Pathogenic mechanisms in rheumatoid arthritis.

London : University of London Audio-Visual Centre, 1972.

1 encoded moving image (35.37 min.) : sound, black and white

00:35:37

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Professor Ivan Roitt, Middlesex Hospital Medical School, London. Introduced by Dr Ian Gilliland. Photomicrographs courtesy of Dr Leonard Glynn. Produced by Peter Bowen. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Gilliland introduces Roitt. Roitt talks about rheumatoid arthritis, particularly the appearance of inflamed joints in the condition. He shows photomicrographs of these, of plasma cells, of lymphoid follicles, germinal centres and mononuclear cells. Time start: 00:00:00:00 Time end: 00:05:16:00 Length: 00:05:16:00

Segment 2 Roitt draws a diagram of a particle coated with human immunoglobulin gene, then attempts to explain how the autoimmune aspect of arthritis begins. Time start: 00:05:16:00 Time end: 00:10:06:00 Length: 00:04:50:00

Segment 3 Roitt continues to discuss, in detail, how rheumatoid factors arise. Time start: 00:10:06:00 Time end: 00:14:15:12 Length: 00:04:19:12

Segment 4 Roitt talks further, with reference to slides and diagrams, about what it is that triggers an autoimmune reaction in the body chemistry. Time start: 00:14:15:12 Time end: 00:19:40:00 Length: 00:05:24:13

Segment 5 Roitt describes how antiglobulin levels are very high in those with rheumatoid arthritis and refers to research by Barbara Ansell into Still's disease, a rheumatoid condition which affects mainly children. Time start: 00:19:40:00 Time end: 00:25:19:12 Length: 00:05:39:12

Segment 6 Roitt describes which antigens are responsible for reaction with immunoglobulin G to cause rheumatoid arthritis. He lists some of these. Time start: 00:25:19:12 Time end: 00:30:41:12 Length: 00:05:22:00

Segment 7 Roitt concludes the lecture by saying that, as yet, still little is known definitively about the causes of rheumatoid arthritis. Time start: 00:30:41:12 Time end: 00:35:37:20 Length: 00:04:56:20