The constituents of the flowers of Anthemis nobilis / by Frederick Belding Power and Henry Browning, Jun.

  • Power, Frederick B. (Frederick Belding), 1853-1927
Date:
1914.]
Catalogue details

Licence: Public Domain Mark

Credit: The constituents of the flowers of Anthemis nobilis / by Frederick Belding Power and Henry Browning, Jun. Source: Wellcome Collection.

    5/18 (page 1833)
    tion of amyl alcohol extract remaining after the preceding separa¬ tions ether was first added and subsequently chloroform, the result- in precipitates being separately collected, and heated in a current of steam as before for the removal of adhering amyl alcohol. The products which had been treated with steam were separated from the aqueous liquid by filtration, and were thus obtained in the form of brown, viscid masses. Isolation of an Apigenin-d-glucoside, C21II20O]0,II2O. As all the above-mentioned portions of brown, viscid material were similar in character they were mixed, and then separated several times from large volumes of very dilute alcohol. It was thus obtained in a form which permitted of its being dried, but if smaller volumes of solvent were used the material was deposited as an oil. After further successive separations from 30 per cent, acetic acid, and alcohol of about 20 per cent, strength, the material was finally obtained in microscopic crystals having a slightly yellow tint. This crystalline substance melted and decomposed at 178—180°, and was found to be a glucoside. Considerable difficulty was experienced in drying the substance, on account of its great avidity for moisture. It was practically devoid of bitterness, and possessed only a slightly astringent taste. Its aqueous solution gave with alkalis a lemon-yellow colour, and with ferric chloride a purplish-brown coloration was produced: 0* 1321, heated at 125—130° for several days, lost 0*0106 H20. H20 = 8*0. 0*3528, dried in a desiccator over calcium chloride, lost 0*0282 HoO. Il2O = 8*0. 0*1215 * gave 0*2487 C02 and 0*0543 II20. C = 55*8; H = 50. 0*1820 f „ 0*3733 C02 „ 0*0826 H20. C = 55*9; H = 5*0. C21II220I1 requires C = 56*0; 11 = 4*9 per cent. C2iH220ii,2H20 requires H20 = 7*4 „ „ It will be seen from these results that the above-described sub¬ stance, when subjected to prolonged drying at 125—130°, or when dried over calcium chloride, agrees in its empirical composition with the formula C21H22On, whilst the loss of water under the conditions mentioned is equivalent approximately to two molecules. No further amount of water could be removed from the substance, since at a temperature above 130° it showed a tendency to soften and decompose. A consideration of the composition of the acetyl derivative and hydrolytic products of the substance rendered it evident that it * Diied at 125—130°. t Dried over calcium chloride.