Action of decamethonium iodide (C 10) on the demarcation potential of cat's muscle / B. Delisle Burns, W.-D.-M. Paton and M. Vianna Dias.

  • Burns, B. Delisle (Benedict Delisle)
Date:
[1949?]
Catalogue details

Licence: In copyright

Credit: Action of decamethonium iodide (C 10) on the demarcation potential of cat's muscle / B. Delisle Burns, W.-D.-M. Paton and M. Vianna Dias. Source: Wellcome Collection.

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    ACTION OF DECAMETI-IONIUM IODIDE (C 10) ON THE DEMARCATION POTENTIAL OF CAT’S MUSCLE. B. Delisle BURNS, W.-D.-M. BATON and. M. VlANNA DIAS. (The National Institute for Medical Research, Hampstead, London, N. W. 3.) Ui .. It has been observed [Paton & Zaimis, 1949] that deeamethonium iodide (a : w-bistrimethylammonium decane diiodide : also called Cio) causes neuromuscular block, but that its properties differ in several important (respects from those of c?-tubocurarine chloride. Thus, Cio elicits a contrac¬ ture of frog’s rectus ; its paralysing action is antagonized by its pentane homologue (C5), but not by antiesterases; and the previous administration of d-tubocurarine chloride also reduces its action. Consideration of these (properties suggested that Cio might act differently from d-tubucurarine chloride and that this might involve a depolarizing activity. This communication presents the results of experiments studying the action (of Cio and other drugs on the resting potential of mammalian muscle. In cats anaesthetized with chloralose, demarcation potential (DP) was recorded rom the tibialis muscle [Brown & Goffart, 1949]; the muscle was pre¬ pared for close arterial injection and was burned at the distal end; in some experiments, twitch tension in response to maximal nerve shocks was recorded simultaneously. It was observed that the intraarterial injection of 2fig. of Cio produced a fall of 30 to 50 p. 100 of the recorded demarcation potential, proceeding rapidly or 10-15 seconds, then slowly for 5-10 minutes, with recovery in 10-30 minutes roughly parallel to the neuromuscular paralysis. Similar falls olio wed 30-40 fig./kg. intravenously. No dose, however big, caused a Repression exceeding 60 p. 100 of the demarcation potential. Small doses 0.2-0.5 fig. intraarterially) which caused only potentiation of the muscle witch, elicited also a small but definite fall in DP. J. P. 031682. 7