The influence of magnesium sulphate on the secretory activity of the digestive glands / by W. Horsley Gantt and G.V. Volborth.

  • W Horsley Gantt
Date:
[1930?]
Catalogue details

Licence: In copyright

Credit: The influence of magnesium sulphate on the secretory activity of the digestive glands / by W. Horsley Gantt and G.V. Volborth. Source: Wellcome Collection.

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    TABLE VI. — “SNEJOK,” JANUARY 6, 1926. THE LOCAL ACTION OF MAGNESIUM SULPHATE (15 PER CENT SOLUTION) ON THE MUCOUS MEMBRANE OF THE STOMACH. 11:40—Dog brought on stand. 13:00—1.2 cc.; acid. 13:15—0.2 cc.; acid. 13:15-20 50 cc. of 15 per cent magnesium sulphate solution run through the Pavlov pouch. 13:20-22—Allowed to drain off. 13:22-28—0.5 cc., neutral. 13:35—0.2 cc, neutral. 13:50—0.3 cc. 14:05—0.0 cc.; mucous membrane is slightly alkaline. 14:20—0.2 cc.; slightly alkaline. For eighty minutes before the experiments: 1.4 cc.; slightly acid. For sixty minutes after the magnesium sulphate: 1 cc.; slightly alkaline. acid reaction. A typical protocol, which also shows the close parallel between the main and isolated stomach, follows: TABLE VII. — SIMILAR EFFECTS IN STOMACH AND PAVLOV POUCH. 1:30—On stand. 2:15—Tube inserted. 2:15—Alkaline. 2:15-30—0.2 cc.; alkaline. 2:45-53—Alkaline, Pavlov pouch; large stomach neutral; stomach washed with 400 cc. distilled water, 100 cc. at the time, so as not to distend. 2:53—Pavlov pouch alkaline; large stomach neutral. 2:58—Alkaline Pavlov pouch. 2:47-3:02—0.4 cc.; Pavlov pouch, alkaline. 3:17—5 cc.; Pavlov pouch, mucoid. 3:22—Alkaline, both Pavlov pouch and large stomach. 3:23-28—28 gm. of magnesium sulphate in 56 cc. water (33.33 per cent solution in gastric fistula at room temperature; dog on back; recovered 30 cc. clean colorless fluid; no signs of nausea. 3:30—Alkaline in both stomach pouch and large stomach. ‘v Pavlov pouch. Large stomach. 3:30-45 . . 0.4 cc.; alkaline 12 cc.; alkaline. 4:00 . . 0.4 cc.; slightly acid 6 cc.; neutral. 4:15 . . 0.3 cc.; slightly acid 2 cc.; very slightly acid. 4:30 . . 0.4 cc.; slightly acid 0 cc.; slightly acid. 4:33-35 . . . • • • • 2 cc.; green-yellow fluid • • • • like mixed acid and bile. 4:30-45 . . 3 cc.; acid. 4:45 . . 0.5 cc.; acid. We often also obtained bile in the large stomach, accompanied by retching and vomiting. This will be referred to in a subsequent paper. The presence of the alkaline reaction in the isolated Pavlov pouch shows that it could not have been due to the regurgitation from the duodenum. Our experiments show that magnesium sulphate acts as a weak irritant to the mucous membrane of the stomach. The effect on the gastric secretion was nearly the same whether the magnesium