Volume 1
A case of malarial fever, showing a true parasitic relapse, during vigorous and continuous quinine treatment / by Sir Ronald Ross and David Thomson.
- Ronald Ross
- Date:
- 1912
Licence: Public Domain Mark
Credit: A case of malarial fever, showing a true parasitic relapse, during vigorous and continuous quinine treatment / by Sir Ronald Ross and David Thomson. Source: Wellcome Collection.
3/10 page 539
![[Reprinted from the‘ Annals of Tropical Medicine and Parasitology,’ Vol. V, No. 4, February, 1912] 539 A CASE OF MALARIAL FEVER, SHOWING A TRUE PARASITIC RELAPSE, DURING VIGOROUS AND CONTINUOUS QUININE TREATMENT BY DIR Neon Goo, bh C.bHior IR. 3: AND Peover MoON M.be CH BY? DP TE: (Recezved for publication 12 February, 1912) In the ‘ Annals of Tropical Medicine and Parasitology,’ Vol. V, No. 3, December 30, 1911, we described the occurrence of pseudo or non-parasitic relapses in 6°7 % of our cases of malarial fever, during active quinine treatment of ten grains thrice daily. We were unable to prove that these ‘ pseudo-relapses,’ which usually took the form of a sudden and isolated rise of temperature, had any connection with the original fever, as similar inexplicable rises of temperature occurred in 17 % of other diseases, during treatment in hospital. Cases of malarial fever, resistant to quinine treatment, and which showed relapses during the treatment have been reported to occur in the Amazon region. During our experience of two years of careful observations on cases of malaria, we found no case which showed any resistant tendency to quinine, and twenty of these cases had contracted fever up the River Amazon. We, therefore stated in our paper (1911) that it was possible that these so-called resistant cases might have been cases of pseudo-relapses, especially as no data had been given with regard to the finding of parasites in them. We are now able, however, to confirm these reports, having observed carefully a case which showed marked resistance to quinine, and which showed a true parasitic relapse during treatment with that drug. The details of this remarkable case, of which we publish a chart, are as follows :—](https://iiif.wellcomecollection.org/image/b33438018_0001_0003.jp2/full/800%2C/0/default.jpg)
