Studies upon plague in ground squirrels (in four parts) ... : II. A plague-like disease of rodents / by George W. McCoy.

  • McCoy, George W.
Date:
1911
Catalogue details

Licence: Public Domain Mark

Credit: Studies upon plague in ground squirrels (in four parts) ... : II. A plague-like disease of rodents / by George W. McCoy. Source: Wellcome Collection.

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    SUSCEPTIBILITY OF MONKEYS TO INFECTION WITH THE BACILLUS FOUND IN GROUND SQUIKRELS. Monkeys have usually been found to be quite susceptible to infec- tion with plague. This refers to the strains derived from human cases and from rats. It seemed worth while determining the susceptibility of these animals to the cultures isolated from ground squirrels in California. A monkey (Java) was vaccinated with a culture of B. pestis isolated about three months before directly from the heart’s blood of a natu- rally infected squirrel. A guinea pig, a white rat, and a ground squirrel, all vaccinated, served as controls. The results are shown in the following table: {Culture from squirrel 701, seventh generation on agar.] Day of Animals. Beate Lesions. SMES ull. soe, SSE Ey go Ook Ase oe = SERS Kighth..| Acute plague. WRITE AG Sen fees sees a= Saeecemcci ence sss telieel 5. co eemoeboe oe Sixth. : Do. (OGLE OVERS 2 Ska SL Ee SE AR SE oc el ee I 2 SEA Seventh.| Subacute plague. GOUMIG IN CFIET CL emer eins =. = oe Wales ears ain ise $ ~ e's'sc «\~ =’ Sle ememteetenicle face dorse. Do. A pure culture of B. pestis was isolated from the spleen of the monkey. SUSCEPTIBILITY OF WHITE MICE, We have not conducted any experiments for the express purpose of learning the susceptibility of white mice to the squirrel strain of B. pestis. However, afew of these rodents have been used in immu- nity investigations. Four were vaccinated with a culture of the squirrel plague bacillus. Three died of acute plague; the fourth remained well. SUSCEPTIBILITY OF WHITE RABBITS. Six of these animals were vaccinated with 48-hour agar cultures of B. pestis, a culture isolated from a different naturally infected squirrel being used for each. Guinea pigs and white rats served as controls. The results are shown in the following table: Day of death. cae White rabbit. White rat. Guinea pig. 245/35. 5 ees 'g Fourth; acute plague........| Seventh; acute lague.......| Remained well. 665/2.-.3-¢ Sixth; acute plague......... Fourth; acute plague........ Pima killed; small purulent ubo. I Sia ax sos Ninth; killed; caseous bubo.} Seventh; acute plague.......) Fifth; acute plague. 361/83... 225 Seventh; acute plague..... - ‘|, Ninth; killed; negative...... Remained well. Be SH wate Do. 396/3 Lorase Fifth; acute plague .......-.. Ninth; killed; negative...... Tenth; subacute plague.
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