[Beta]-iminazolylethylamine : a depressor constituent of intestinal mucosa / by G. Barger and H.H. Dale.

  • Barger, George, 1878-1939.
Date:
[1911]
Catalogue details

Licence: In copyright

Credit: [Beta]-iminazolylethylamine : a depressor constituent of intestinal mucosa / by G. Barger and H.H. Dale. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    13 [.Reprinted from the Journal oj Physiology, Vol. XPf. tfo^Gfwuary, 1911.] -IMINAZOLYLE STITUENT OF G. BARGER and DEPRESSOR CON- STINAL MUCOSA. By H. H. DALE. (From the Wellcome Physiological Research Laboratories.) The description of a symptom-complex common to the action of commercial “ peptone ” and of extracts of certain organs, such as intestine, brain, thyroid gland, etc. has formed the subject of numerous papers by Popielski and his co-workers1. Lohmann2and von Fiirth and Schwarz3 have identified choline as a depressor constituent of such extracts, but, as Popielski and his followers have made clear, the very marked depressant action of these extracts cannot be entirely due to choline, whatever be the final outcome of the discussion as to whether pure choline is depressant. The effects attributed by Popielski to the hypothetical “ vaso-dilatin ” include fall of blood-pressure, due to vaso-dilatation ; loss of coagulability of the blood ; violent peristalsis, contraction of the bladder; accelerated secretion of saliva, pancreatic juice and, to a less extent, of bile; depression and narcosis. He regards as fundamental effects the fall of blood-pressure, due to “ paralysis of the peripheral vasomotor apparatus,” and the abolition of the coagu- lability of the blood, the other effects being secondary to these. He identifies the “secretin” of Bayliss and Starling with “vaso-dilatin,” so that the action of secretin on pancreatic secretion is, according to his view, a secondary and non-specific effect. Though the repeated association of certain actions is suggestive, it by no means amounts to a proof that they are all produced by a single chemical substance. One of us recently, in conjunction with 1 Popielski. Pflilger's Archiv, cxxvm. p. 191, 1909. Modrako wski. Ibid, cxxxin. p. 291. 1910. Kef. Zentralbl. f. Physiol, xxii. p. 610. 1908. 3 Pflilger's Archiv, cxxm. p. 361. 1908. PH. XLI. 33