[Beta]-iminazolylethylamine : a depressor constituent of intestinal mucosa / by G. Barger and H.H. Dale.

  • George Barger
Date:
[1911]
Catalogue details

Licence: In copyright

Credit: [Beta]-iminazolylethylamine : a depressor constituent of intestinal mucosa / by G. Barger and H.H. Dale. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    might be expected, a little more active than B, which contained 01 °/0 of hydrochloride. (2) 1 c.c. of solution A, injected intravenously into a cat under ether, caused a fall of arterial blood-pressure and increase in volume of a fore-limb (Fig. 2), identical with that produced by the same dose of B. Fig. 2. Effeot of 0 5 mgm. of base from intestines on limb-volume and blood-pressure. (3) 1 c.c. of A and 1 c.c. of B produced similar rises of blood- pressure in a rabbit which had been for one hour under urethane at the time of the injection. (4) 1 c.c. of A injected into the external saphenous vein of an unanEesthetised guinea-pig caused death from asphyxia in six minutes, with the characteristic permanent distension of the lungs, due to firm contraction of the bronchioles. A precisely similar effect was obtained by Dale and Laidlaw with 0-5 mgm. of 0-1. In physiological action, therefore, as in chemical characters, the base is indistinguishable from 0-1., and the identification may be regarded as complete. The yield of pierate which we obtained corresponds only to a small fraction of the activity of the original extract on the blood- pressure or the isolated uterus. The losses, however, due to the unmanageable nature of the bulky precipitates produced, are necessarily very great, and the small yield cannot be regarded as disproving the possibility that 0-1. is responsible for practically the whole of the activity in these directions of the original extract. On the other hand it is possible that other substances of somewhat similar action are present.
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