The action of chloroform upon the heart and arteries / by E.A. Schäfer and H.J. Scharlieb.

  • Edward Albert Sharpey-Schäfer
Date:
1904
Catalogue details

Licence: In copyright

Credit: The action of chloroform upon the heart and arteries / by E.A. Schäfer and H.J. Scharlieb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    The same Kidneys, later: Amount flowing before chloroform perfusion . . . 61 c.c. „ „ during „ „ (1 in 5000) 67 ,, „ „ during „ „ (1 in 2000) 70 „ Subsequent perfusion with suprarenal produced strong constriction, showing that the arterioles were still active. The effects of stronger and weaker solutions upon the kidney vessels is also well illustrated in the accompanying tracings, which show (in fig. 1) the effect (marked constriction of vessels with rise of pressure Fig. 1.—Perfusion of rabbit’s kidney with Ringer’s solution. At the time marked by the signal 4 c.c. of the same solution, containing 0’5 per cent, of chloroform, and at the same temperature, was slowly injected into the supply tube. The mixture of this solution with that passing through the tube at the time gave a fluid containing 0‘2 per cent. (1 in 500) actually perfused. Notice the rise of pressure due to constriction of the bloodvessels, followed after the passage of the fluid by a dilatation ; also the great diminution in outflow, followed by a slight increase. a, Register of mercury manometer ; b, movements of “ see-saw,” registered by air transmission : each up or down move- ment represents 7 c.c. of fluid discharged ; c, time in 10 secs. ; d, signal line and pressure abscissa. Fig. 2.—Tracing similar to that shown in fig. 1, but with injection of 4 c.c. of 1 in 1000 chloroform, and actual perfusion of 1 in 6000. Notice the fall of pressure and the increase in rate of discharge, indicating dilatation of arteries. and great diminution of flow) of perfusing a solution of Ringer containing 1 in 500 chloroform; and (in fig. 2) the effect (dilatation of vessels with fall of manometric pressure, and increase of rate of flow) of passing a solution containing 1 in 6000 through the kidney. Heart of Cat: Amount flowing through coronary system before chloroform ..... 44 c.c. „ „ ,, ,, „ during „ (l in 10,000) . . . 41'5 ., ,, ,, ,, ,, „ after „ ..... 44 „
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