Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson.

  • Milton Rosenau
Date:
1907
Catalogue details

Licence: In copyright

Credit: Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson. Source: Wellcome Collection.

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    GROUP E. FAMILY NO. 16. (Untreated feinala; sensitized male.) Female (G. P. No. 606). Se.]>tember 7, 1906. Six c. c. horse serum intraperi- toneally. No prior treatment. No symptoms. Male (G. P. No. 606x). September 9, 1906. Six c. c. horse serum (roan) intraperi- toneally. Dead, 17 minutes. [Previous treatment: 106 days prior received 0.15 c. c. tox. c. antitoxic horse serum (Natl. VIII, 18).] Offspring-. Two young born August 4, 1906, and tested as follows: (G. P. No. 606a.) September 9, 1906. 1 month old. Two c. c. normal horse serum into peritoneum. No symptoms. (G. P. No. 606b.) September 9, 1906. 1 month old. Two c. c. normal horse serum (roan) into peritoneum. No symptoms. FAMILY NO. 17. (Untreated female; sensitized male.) Females (G. P. No. 609). January 25, 1907. Six c. c. normal horse serum (horse No. 15), intraperitoneally. No prior treatment. No symptoms. (G. P. No. 607). Ditto. No prior treatment. No symptoms. Male (G. P. No. 4527). January 25, 1907. Six c. c. normal horse serum (horse No. 15), intraperitoneally. Dead, 37 minutes. [Previous treatment: 1 year 13 days prior, 0.19 c. c. toxine No. 7+1 unit B27.] June 8, 1906. Placed with untreated females Nos. 609 and 607. Offspring-. December 26,1906. Three young born to G. P. No. 609. September 6, 1906. One young born to G. P. No. 607. Young tested as follows: (G. P. No. 609a). January 25, 1907. 30 days old. Two c. c. normal horse serum (horse No. 15) intraperitoneally. No symptoms. (G. P. No. 609b). Ditto. No symptoms. (G. P. No. 609c). Ditto. No symptoms. (G. P. No. 607a). Ditto (141 days old). No symptoms. We conclude from these experiments that— 1. H3’persusceptibility to the toxic action of horse serum is trans- mitted through the female guinea pig; the male has no influence. 2. The susceptibility^ is not transmitted through the milk. 3. Maternal transmission of hy-persusceptibility^ succeeds, -whether the female guinea pig is sensitized before or after conception.