Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson.

  • Milton Rosenau
Date:
1907
Catalogue details

Licence: In copyright

Credit: Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson. Source: Wellcome Collection.

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    THE INFLUENCE OF TETANUS TOXINE UPON HYPERSUSCEPTIBILn~V. Bcsredka and Stcinhavt intimate- that guinea ]jigs seiiKilized with a mixture of tetanus toxine and antitc'tiinic serum are not sensitive to subsequent injections of horse serum. These scientists, liowever, sug- gest that their failures on this point may have been due to the small amount of horse serum used at the lirst injection, viz, and TuAu'D C. c. We tested some of our used tetanus guinea pigs to determine this point and found that tetanus toxine does not apparentl}' influence the phenomenon of hypersusceptibilit}^ to horse .sei’um. The guinea yjigs were sensitized with 0.0006 gm. of a dried tetanus toxine, which rep- resents 100 minimal lethal doses, plus various amounts of antitetanic serum. All those tested reacted to a second injection of horse .serum. Tetanus toxine. No. - G. P. 438 439 444 447 451 First injection. 0.0006 gm. tetanus tox- ine A + c. c. anti- toxic horse serum (H oechst) subcuta- neously. 0.0006 gm. tetanus tox- ine A + Yhf c. c; anti- toxic horse serum (Hoechst) subcuta- neously. 0.0006 gm. tetanus tox- ine A-j-T^ViT anti- toxic horse serum (Hoechst) subcuta- neously. 0.0006 gm. tetanus tox- ine A+^^j (M2122) c. c. antitoxic horse serum subcutaneous- ly- O.OOO6 gm. tetanus tox- ine A(Pk) c. c. antitoxic horse serum subcutaneously. 440 0.0006 gm. tetanus tox- ine A “1“ (Hoechst) c. c. antitoxic horse serum subcutane- ously. Interval. Days. 17 17 28 28 28 28 Second injection. Result. 6 c. c. normal horse (roan) serum, in- traperitoneally. Dead, .30 minutes. do Dead, 30 minutes. do Very severe symp- toms. • do Very severe symp- toms. 6 c. c. normal horse (roan) serum, in- traperitoneally (Pasteur Insti- tute). Dead, 10 minutes. do Dead, 10 minutes. THE RELATION OF THE SPLEEN AND THYROID TO HYPERSUSCEPTIBILITY. While we believe that this reaction is probably localized in the cen- tral nervous system, several experiments were undertaken to deter- mine what influence the spleen or the thyroid gland may ha\ e upon the hypersusceptibility produced hy the injection of horse serum. «Ann. Pasteur Inst., Vol. 21, No. 2, 1907, pp. 117 127.