Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson.

  • Milton Rosenau
Date:
1907
Catalogue details

Licence: In copyright

Credit: Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson. Source: Wellcome Collection.

    63/76 (page 61)
    MISCELLANEOUS. FEEDING EXPERIMENTS WITH COOKED MEAT. In our former work wo showed that guinea pigs may be sensitized by feeding them blood serum or meat. We know that heating blood serum to 100° C. for fifteen minutes is sufficient to destroy its toxic action. We then asked ourselves the question, Would the heating of meat prevent the sensitizing action? The following experiments indi- cate that heat does destro}^ this property of meat, as far as the guinea pig is concerned. In these experiments well-cooked horse meat was used. It was heated in the hot air sterilizer at 110° C. for thirty minutes. Two grains of it was fed to the animals daily from June 15 to June 30. Each guinea pig, therefore, received 32 gm. of the cooked meat. None of them showed s3miptoms when injected eighteen claj^s later with 6 c. c. of normal horse serum. Xo. G. I’. First treatment. Interval. Second treatment. Re.sult. 496 Fed 2 gm. horse meat, Dans. 18 6 c. c. normal hor.se No symptoms. 497 heatefl to 110°C. (hot air) 30 minutes, daily for 16 days. do 18 (roan) serum, in- traperitoneally. do No .symptoms. No symptoms. No symptoms. No symptoms. 498 do 18 do 499 do 18 do . .'SOO do 18 do FEEDING EXPERIMENTS WITH RAW BEEF. We know that guinea pigs fed with horse serum or horse meat are susceptible to subsequent injections of horse serum, and we are now able to show, by the following series of experiments, that guinea pigs fed with beef are susceptible to subsequent injections of cattle serum: No. G. K First treatment. Interval. Second treatment. Result. .501 Fed 2 gm. drittd beef Dans. 19 6 c. c. cattle serum. Mild svm])toms. 502 daily for 23 davs. do I 19 intraperitoneally. do Mild symptoms. Severe symptons. .503 do 19 do (Gl)