Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson.

  • Milton Rosenau
Date:
1907
Catalogue details

Licence: In copyright

Credit: Studies upon hypersusceptibility and immunity / by M.J. Rosenau and John F. Anderson. Source: Wellcome Collection.

    65/76 (page 63)
    % which 378 dii}’s elapsed bet.ween the hi’st treatment and the second injection. No. ci. r. 45 lo 4527 4495 4495a 4495b First injeiitioii. Interval. Second injection. J)atis. 6 c. e. normal horse 0.19 c. c. toxine 7-|-l 238 unit antitoxic horse (roan) serum, in- traperitoneally. serum (B. 27), sub- eutaneously. do 378 6 c. c. normal horse do 365 (No. 15) serum in- traperitoneally. do Ditto, 2 days later.. Two young, horn of above female (4495), te.sted as follows: When 7 days old, 1 c. c. normal horse (No. 15) serum, intraperitoneally. When 9 days old, 1 c. c. normal horse (No. 15) serum, intraperitoneally. Result. Dead, 30 minutes, Dead, 37 minutes. No symptoms. Severe symptoms. Dead, 13 minutes. Dead, 12 minutes. The above guinea pig (No. 4495) showed no sjmiptoms at all after receiving 6 c. c. of horse serum into the peritoneal cavity 365 days after the tirst injection. It was then given the same quantity of serum two days following and showed severe symptoms. We have bad several such instances following intraperitoneal injections, and can only explain it by the fact that sometimes the serum enters the lumen of the intestine instead of the peritoneal cavity. AVe called attention to this probability in Hygienic Laboratoiy Bulletin No. 29, page 63. THE EFFECT OF FIRST INJECTIONS OF HORSE SERUM INTO GUINEA PIGS. Theobald Smith stated that guinea pigs which have received no preliminary doses of .serum ma}^ die of a fii’st injection; of 58 guinea pigs receiving 3 to 5 c. c. of diphtheria antitoxin with no preliminaiy treatment, 9 died and 49 showed no effect, making 15.5 per cent of the guinea ]iigs reacting to the first injection of horse serum. In reply to a question. Smith stated that he did not know whether or not the animals were the young of guinea pigs that had been treated. We have injected many guinea pigs with horse serum and have never noted symptoms of death to follow the first injection, and can not help hut believe that the results obtained by Smith are explained by our studies upon the maternal transmission of hypersusceptibility. Smith, Theoi)akl: DiscusHioii of liosenau and Anderson’s paper on “HypersuS' eeptibility.” Journ. Am. Med. Assn., Vol. 27, No. 13, Sept. 29, 1906, p. 1010. i