Scientific reports on antipyrin : collected from the principal medical publications of the world / [Dr. Knorr].
- Date:
- 1890
Licence: Public Domain Mark
Credit: Scientific reports on antipyrin : collected from the principal medical publications of the world / [Dr. Knorr]. Source: Wellcome Collection.
Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.
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![Since the publication of his first researches [Breslauev avztl. Zeitschrift, 1884, N. 11) the author made further investigations on a more extended scale. A further number of 51 patients, suffering from different kinds of fever, were treated with Antipyrin. With only one exception (mitral endocarditis with rheumatic fever), he succeeded in all cases in reducing the febrile tempera- ture to its normal level, and in keeping it down for a considerable time. The necessary dose varied between 30 and 90 grains (very rarely 120—150 grains), and between 4 and 20 grains with chil- dren. With the latter, the daily quantity was divided into several single doses of 4 grains each. In intermittent., fever, Antipyrin caused lessening of the fever, but a cure was not effected. Typhoid fever seemed to be of a milder character when treated with Antipyrin. Of secondary effects vomiting was again observed; to avoid it Antipyrin was successfully applied per rectum (dose: 30 grns.— [6 Tabloids]—dissolved in 6 ounces of water). It was also supplied subcutaneously, but this method was given up again. Novel was his observation, that Antipyrin sometimes caused an eruption. He saw this in several cases of typhoid fever; the exanthema was itching and much resembled that of ordinary measles. It disappeared without desquamation even when Anti- pyrin was continued and did not cause the patient any discomfort. In one case miliaria alba of a very characteristic nature was ob- served after 90 grains of Antipyrin had been given. A case of typhoid fever combined with Antipyrin rash was at first mis- taken for typhus. With regard to rheumatic fever the author modifies his former statement, and believes that in this disease Antipyrin not only has an antipyretic effect, but also that it acts favourably on the affec- tions of the joints. In six out of eight cases of acute rheumatic arthritis a speedy recovery was obtained; in one subacute, pro- longed case, Antipyrin undoubtedly effected marked improve- ment ; only once it failed to act on the joints, whilst its antipy- retic effect was in evidence. In rheumatic fever the drug was given in full doses until the temperature remained normal, and](https://iiif.wellcomecollection.org/image/b21455375_0015.jp2/full/800%2C/0/default.jpg)
