Volume 1
The extra pharmacopœia of Martindale and Westcott.
- William Martindale
- Date:
- 1920-1921
Licence: Public Domain Mark
Credit: The extra pharmacopœia of Martindale and Westcott. Source: Wellcome Collection.
130/1212 page 88
![The main point of the paper appears to be that in the 6 persons already referred to, receiving toxic doses of Aspirin, there was a total excretion of un¬ changed Aspirin ranging from 8' 8 % to 86' 6 % of the Aspirin taken, and, broadly speaking, that a considerable amount of unchanged Aspirin would circulate through the body in such cases. The investigation is of interest but the con¬ ditions do not seem to be in agreement with ordinary therapeutic developments. For further details, also for Bactericidal Action vide Voi, 11. Mistura Acidi Acetyi-Salicylici. Dose.—| ounce=10 grains. Acetyl Salicylic Acid in fine powder 10 grains, Tragacanth Mucilage 90 minims. Water to \ ounce. If it be desired to prescribe the acid in a mixture the above formula will serve, providing it is not kept too long,particularly in hot weather. Tablets are prepared weighing 5 grains (0-3 Gm.), and 8 grains (0-5 Gm.). These should not he swallowed whole. Also Tablets of Acetyl-Salicylic Acid 5 grains with Phenacetin 21 grains each and |FJ] [g| with Dover Powder 24 grains. Acute febrile diseases—measles, pneumonia, diphtheria and sepsis generally—treated by the following combined : Aspirin 10 grains, Phenacetin 5 grains, Compound Ipecacuanha Powder 15 grains, with striking effects. Inflammation reduced at site of origin, with sweating and rail of temperature.-—It. J. G. Parnell and co-workers, B.M.J. ii./22,I000. The combination is highly spoken of by others ; valuable during the paroxysms of malaria, ibid., p. 1097. See also L. ii./23,1422. Aspirin and Pfaenoqum—combined powders 7|- grains each, followed in the morning by a brisk Saline aperient, useful. Better than Aspirin alone in producing a profuse perspiration.—N.Y.M.Jh, Mar./2o, 459, per Pres., Peb,/2i,85. Aspirin Tablets made with 1J- molecules of Sodium Bicarbonate to 1 mole¬ cule of Acid subject of a Patent.—P.J. i./is,768. Elixir Sodii Brom-Acetosalicylatis. Dose—ounce repeated each hour if necessary until 4 doses have been taken. Contains the equivalent of 10 grains of Acetyl-Salicylic Acid and 10 grains of Sodium Bromide in 1 ounce. Antipyretic. Relieves ehroifci articular rheumatism, and may be tried for vague neuralgic pain.—W. W. W. References to Acetyl-Salicylic Acid. Acetyl-Salicylic Acid,Patent Case, P.J i./o5,672,700.—,JudgmentP.J.ii /o5,76s see also P.J. ii./o7,424 Chorea,—the drug par excellence. Large doses (40 grains) four hourlv to a child of six. Best given suspended and flavoured, c.g., Aspirin 10, Gum Acacia q.s., Syrup of Orange 30, Chloroform Water to 120. A dessertspoonful dose = 10 grains.—J. Allan. Pies. Feb. 1013,51. Pneumonia in Southern India. Good results in eight cases—not of a rheumatic origin as acute rheumatism is unknown in the locality. Early stages 8 to 10 grain doses of Aspirin given. Respirations and pulsedell satis¬ factorily after crisis in each case.—L. i./is,786. Acute nisal catarrh, prophylaxis of—Aspirin in 20 grain doses three times a day. Magical in the acute attacks.—B.M.J. ii./i3,886. Extensive syphilitic periostitis,—to relieve. Large doses of Acetyl-Salicylic Acid—3 to 4 Gm. pci. for nine years—making a total of over 26 lbs. No by-effects providing bowels opened freely. On an empty stomach there was often pain—probably from the enhancing of the acidity. No ill effect even when combined with Mercury, Saivarsan, etc—P.J i./i3,150.](https://iiif.wellcomecollection.org/image/b31360440_0001_0130.jp2/full/800%2C/0/default.jpg)
