Volume 1
The extra pharmacopœia of Martindale and Westcott.
- William Martindale
- Date:
- 1920-1921
Licence: Public Domain Mark
Credit: The extra pharmacopœia of Martindale and Westcott. Source: Wellcome Collection.
73/1212 page 31
![The coumarates have action of vasodilators, and they may be taken for prolonged periods without harm.—Oliver. Sodii Ortlio-Coumaras. C9H7O3Na=186T01. This salt is best used in the form of Injsctio Sodii Ortho-Ooumaratis; a 22% aqueous solution. Bose.—25 minims (1*5 Cc.b Injected thrice weekly when possible betiveen the malignant growth and healthy subjacent tissues or in the course of lymphatics proceedin'] from the region of the growth, or over a large serous sac like the peritoneum. This injection is a clear yellow liquid perfectly stable. In glandular and early cases of pulmonary tuberculosis Drage reported good results with the injection. In cancer, greater difficulty is experienced, owing to the variation of the disease ; but Drage held th at very few drugs exert more definite action. Cancer, inoperable in a man of 74, well treated by this salt and sodium cinnamate with * X ’ ray irradiation. Papilloma on middle third of left vocal cord similarly, with result that pain disappeared, voice improved, which previously had been quite out of control. Injections were made into the pleural cavity, in a case of malignancy either in the pleura or in the root of the lung, after removal of large volumes of fluid. There was some sign of efficacy, though transient.. —A private communication (19?^. Sodium Qrtho-Coumarate Sterules contain 25 minims of the above injection. They are also made with Kerocain 1 grain ; also with Kerocain 4 grain and Adrenalin Solution 10 minims. Drage obtained good results with this injection. ‘ Fibrocoumarin ’ Sterules contain Sodium Ortliocoumarate injection 25 minims, Thiosinamin 2 grains and Kerocain 4 grain. This is especially suitable where tissue is cicatricised. ‘ Fibrocoumarin ’ Sterules with Adrenalin Solution 10 minim3. Favourable results have been obtained by injection of this preparation into the growth. Drage stated it is the most active local agent he had used. cf. also Cicatricine for a simple solution of Thiosinamin. 5)eTyllUarm (T. M. 283966). Syn. Acidum Acetyl-O-Coumaricum. A V O.CO.CHg -CH : CH.COOH =206*135. Dose.—5 to 10 grains (0-3 to 0-6 Gm.) thrice daily after food. Colourless crystals melting at 150° C. This substance constitutes a stage further in the Cinnamic and Coumaric treatment. In view of advantages that acetyl-salicylic acid has over salicylic acid, ortho-coumaric acid has been acetylated. Soluble only slightly in water (easily in presence of alkali, but dissociation occurs), in alcohol 90% 1 in 19, in ether 1 in 50, in chloroform 1 in 16. Uses.—More essentially for malignant disease, but also for tuber¬ culosis and as a general intestinal antiseptic. Any early case of glandular or pulmonary tuberculosis which can bo cured by open-air treatment can be successfully treated with this](https://iiif.wellcomecollection.org/image/b31360440_0001_0073.jp2/full/800%2C/0/default.jpg)
