Volume 1
The extra pharmacopœia of Martindale and Westcott.
- William Martindale
- Date:
- 1920-1921
Licence: Public Domain Mark
Credit: The extra pharmacopœia of Martindale and Westcott. Source: Wellcome Collection.
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![drug accompanied by injections of Sodium Orthocoumarate— it is a valuable adjuvant (Drage). The carbolic acid (Walker-Rideal) coefficient of Tylmarin in 40% alcohol with B. typhosus was found to be 4‘5.—J.T. Ainslie Walker Tylmarin Cachets and Tablets contain 5 grains (0*3 Gm.). Tylmarin Dusting Powder has been used to cancerous growths which have broken down. Large open sores can be materially benefited. Tylmarin Gauze in one yard pieces is prepared for packing for local use. The diminution in size of lymphatic glands secondarily infected has been very marked, and fresh invasion is prevented. No toxic effects have been experienced in the use of any of these methods. A patient with sarcoma in the palate, rendering him practically deaf, received 3 injections of Sodium Coumarate and 5 grains of Tylmarin twice daily. Condition immensely improved. Two cases of carcinoma of the (esophagus improved, also cases of carcinoma of the breast. Success is more likely with definite chemi¬ cals than with undefined ones.—Drage, L. ii./o8,1367. Tylmarin Sodium, Syn. Sodti Aceto-Coumaras. C6H4O.CO.CH3 CH : CH.COONa=228T27. Dose.—5 grains (0-3 Gm.). This substance would be decomposed in the stomach yielding Tylmarin in a nascent condition as initial product. Needle crystals very soluble in water (1 in less than 1) and in Alcohol (90%) 1 in 2. Might also be tried by hypodermic injection. Ty Imam-Quinine. Syn. Quininje Aceto-Coumaras. C20H24N2O2. C6H4O.COCH3.CH : CH.COOH=530‘443. Dose.—3 to 5 grains (0-2 to 0-3 Gm.). White powder containing approximately 60% Quinine and 40% Tylmarin, soluble very slightly in water (less than 1 in 800) in Alcohol 90% 1 in 9, in Glycerin 1 in 30. Antiseptic and febrifuge. Tylmarm-Thorium Syn. Thorii Aceto-Coumaras. Th(OH)4[Th(C6H4 O.CO.CHg.CH: CH.COO)4]2=2405:048 A buff coloured powder containing approximately 35% of Thorium Oxide prepared by double decomposition between Thorium Nitrate and Sodium Aceto-Ooumarate. For local use in malignant disease. We conducted some photographic experiments to determine the radio-activity of this substance. It was found that Tylmarin Thorium and Thorium Oleate (q.v.) were about equal in activity, both being slightly stronger than the Nitrate. The compound may prove of value by hypodermic injection. “ Sterules ” are prepared containing 10 minims of a 10% suspension in Sterilised Almond Oil. Suggested for use in malignant disease on the lines of the other Coumaric preparations. Coumarin. Syn. Coumaric Anhydride, C9H60o= 146-093. This crystalline body which has an aromatic odour and taste is contained in Tonquin beans from Dipteryx ojorata (WTilld.) and D. oppositifoHa (Willd.). (AT.0. Lerjuminosce), also in Woodruff.](https://iiif.wellcomecollection.org/image/b31360440_0001_0074.jp2/full/800%2C/0/default.jpg)
