Imaginal discs : the genetic and cellular logic of pattern formation / Lewis I. Held, Jr.

Cambridge ; New York : Cambridge University Press, 2002.

xv, 460 pages : illustrations ; 29 cm.

Copy 1 Donor: Wellcome Trust Sanger Institute.

Ch. 1. Cell Lineage vs. Intercellular Signaling. Discs are not clones. No part of a disc is a clone, except claws and tiny sense organs. Cells belong to lineage "compartments" -- Ch. 2. The Bristle. Numb segregates asymmetrically and dictates bristle cell fates. Delta needs to activate Notch, but not as a signal per se. Amnesic cells can use sequential gating to simulate a binary code. Notch must go to the nucleus to function. E(spl)-C genes are Su(H) targets but play no role in the SOP lineage. The transcription factor Tramtrack implements some cell identities. Hairless titrated Su(H). Several other genes help determine the 5 cell fates. Pox neuro and Cut specify bristle type. Bract cells are induced by bristle cells.

Includes bibliographical references (p. 307-439) and index.