Lectures on Bright's disease of the kidneys / delivered at the School of Medicine of Paris by J.M. Charcot ; translated with the permission of the author, by Henry B. Millard.

  • Charcot, J. M. (Jean Martin), 1825-1893.
Date:
1879
Catalogue details

Licence: Public Domain Mark

Credit: Lectures on Bright's disease of the kidneys / delivered at the School of Medicine of Paris by J.M. Charcot ; translated with the permission of the author, by Henry B. Millard. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    degeneration ; the greater part are deprived of this epithe- lium, and are carpeted frequently with a row of young cells, which form a new epithelial covering, entirely different from the old one ; finally, many of the tubes are filled with granu- lar or transparent casts. 3d. Outside of this zone are seen the Malpighian bodies, enveloped in a thick capsule com- posed of several layers. The glomerulus itself has under- gone various alterations, which will be considered here- after. I have now placed before you, gentlemen, the elements necessary to the recognition of the topographical disposition of the lesions which exist in interstitial nephritis, and also to the comprehension of the reason of the existence of the granulations. In fact, the alteration specially affects, you perceive, the connective web enveloping the convoluted tubes. This web undergoes in the beginning a transformation into embryonic tissue, and becomes replaced at a later period by a well- organized connective stroma. This connective new-formation has had the effect, doubt- less by compression, of producing atrophy of the convoluted tubes whose epithelium has suffered, become disintegrated, and at a later period has be- come replaced by a lining of young cells ; finally, the parts which compose the region of the labyrinth have become atrophied and collapsed. The central part of the lobule, on the contrary, has remained, relatively, but little altered, and the collecting tubes which compose it mainly, remain with near- ly their normal dimensions. You will easily understand that the salient granulations upon the surface of the kidney correspond to this central part of the lobule ; they pre- sent a color sometimes gray, sometimes red, according as the epithelium of the collecting tubes has become fatty, or, Fig. 15.—Uriniferous tubes, atroj)hied, and containi7ig small cells, partly disintegrated, andfatty granulations. —Magnitude of 420 di- ameters. — Compare the diameter of these atro- phied tubes with those of Fig. 332, drawn after being equally magnified. (Cornil and Ranvier.)