"606" in theory and practice / by Paul Ehrlich and J.E.R. McDonagh.

Paul Ehrlich

Date:: 1911

Credit: "606" in theory and practice / by Paul Ehrlich and J.E.R. McDonagh. Source: Wellcome Collection.

151/166 page 133

$clear up is a strong indication for treatment with ‘606’, owing to such cases being infectious. One does oceasion- ally see cases in which fresh papules come out during treatment, this indicates an immediate re-injection. Tertiary Stage.-—98 cases— 61 intramuscular, 37 intravenous. Rapidity of healing is often remarkable, and is hastened by giving potassium iodide internally and using antisep- tics locally. 5% were refractory, unless the above measures were adopted. Previous arsenical treatment diminished the efficacy of ‘Salvarsan ’. 6% have so far recurred, and with the exception of one case, the lesions healed after the second injection. The second dose must always exceed the first. When recurrences occur Wassermann’s reaction is always positive, although it may have been negative before. Roughly speaking, 60 % give a negative Wassermann’s reaction after one injection, and of the 30 %, 82 % become negative with a second injection. The injection, as in the secondary stage, should be repeated on obtaining a positive reaction after a month’s interval. Nine of these cases have been late tongue lesions, all of which have im-$

"606" in theory and practice / by Paul Ehrlich and J.E.R. McDonagh.

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