"606" in theory and practice / by Paul Ehrlich and J.E.R. McDonagh.

  • Paul Ehrlich
Date:
1911
Catalogue details

Licence: In copyright

Credit: "606" in theory and practice / by Paul Ehrlich and J.E.R. McDonagh. Source: Wellcome Collection.

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    the result that the goal was nearly reached by the dis- covery of arsenophenol, which killed the spirilla of recurrent fever in mice after two injections. Next came the drug which could do the same with one injection, it being called dichlorphenolarsenious acid. Fulfilling as it did my ideal ‘ therapia magna sterilisans ’, the drug could’ never be used clinically owing to the toxic symptoms it produced in animals; mice, for instance, suffered two weeks after a single injection from a severe disturbance of their nervous system, marked by continual shaking movements of the head and neck; the symptoms were progressive, so that finally the mice became dancing mice. Further research revealed a drug, which went by the name of dioxydiamido-arsenobenzol or ‘592’, and its dichlorhydrate ‘606’. The dichlorhydrate was searched for owing to the insolubility of the mother salt, but the action of both is identical. Later Arsenical Compounds.—The arsenical compounds synthesized after the discovery of atoxyl, could only be formed after the formula of the latter had been ascer- tained and when it was found to be an amido derivative of phenylarsenious acid; and, recognizing the range of this group, further experiments were undertaken solely with it, and after arsenophenylglycin had been synthe- sized, its number being ‘418’, nearly two hundred
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