The sulfonamides / Sharp & Dohme.

  • Merck & Co.
Date:
1948
Catalogue details

Licence: Public Domain Mark

Credit: The sulfonamides / Sharp & Dohme. Source: Wellcome Collection.

    17/52 page 15
    (020000 S eee = UunRUBREUBREE COCATNACCEEE TON NEEL aa BEES TERRES 4E0E ELT | IN b+} Nt 4 The effect of varying dosages of succinylsulfathiazole on the coliform bacteria in the gastro- intestinal tract of man. A shows the results of the oral administration of 0.1 Gm. per kilo- gram divided into six equal doses. B represents the effect of the similar administration of 0.2 Gm. per kilogram; C, the effect of 0.25 Gm. per kilogram; D, the effect of an initial dose of 0.25 Gm. per kilogram foliowed after four hours by 0.25 Gm. per kilogram per day in six equally divided doses (this patient had large ulcerating carcinoma of the rectum); E represents the course after the oral administration of three massive doses of 0.25 Gm. per kilogram at four hour intervals followed by 0.25 Gm. per kilogram per day divided into six equal quantities. effective in eliminating dysentery bacilli from the stools of carriers. ‘Sulfasuxidine’ succinylsulfathiazole has been of great value in the preoperative preparation and postoperative treatment of intestinal surgery patients. Because the drug markedly alters the bacterial
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