The contrast in the reactions to the implantation of cancer after the inoculation of living and mechanically disintegrated cells / by M. Haaland.

  • Haaland, M.
Date:
[1910?]
Catalogue details

Licence: Public Domain Mark

Credit: The contrast in the reactions to the implantation of cancer after the inoculation of living and mechanically disintegrated cells / by M. Haaland. Source: Wellcome Collection.

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    mouse-embryo skin ; a fourth with mouse-embryo skin ground at a temperature of about 0° as above. Fourteen days later all these mice, with controls corresponding, were inoculated with 0‘01 c.c. of carcinoma “ 63.” Fig. 1 shows the result of this experiment as observed on the 10th, 17th, 24th, and 31st day after the inoculation. In the control mice there are 17 tumours in 18 mice, i.e. 94 per cent. The mice treated with fresh embryo-emulsion |-I8 CONTROL NORMAL MICE. AV. WT.I5.GR 12/ '3 V /$ 26/ /3 7, 1 9 9 t 2 t ft ? f 3 / 1 1 1 4 1 * 4 # 5 1 % % V 1 6 • 9 $ % 7 • * ft $ 8 • f f # 9 t « ft < ft • 10 0 ® • II • 9 s> 12 • o « 13 • f t 1 14 - * « • • 15 t. • • 16 * • c e 17 • 9 18 - - - 69-28 TREATED WITH TOTAL MOUSE EMBRYO FRESH IS DAYS PREVIOUSLY. O-iOcC. LEFT AX. AV.WT.I4.GR. 10 cm. Lu.u..Uj_uJ 20-37 TREATED WITH TOTAL MOUSE EMBRYO FROZEN AND GROUND 14 DAYS PREVIOUSLY. 0-S0CC. LEFT AX. A V. WT.I4-4.GR. .2/ /3 19/ A 28/ A X 29 • l t 30 ft t 31 • 1 i 32 • f a 33 / / ) » 34 i • « ft « 35 • « 9 36 ft 9 f t 37 t 23— 5? TREATED WITH MOUSE EMBRYO SKIN FRESH 14 DAYS PREVIOUSLY. QSB CG. LE FT AX. 52-02 TREATED WITH MOUSE EMBRYO SKIN FROZEN gCAEL^AND GROUND 14 DAYS PREVIOUSLY. 0-10 CC. LEFT AX. AV. WT.I2-3.GR. 12/ A /3 26/ A y / 4 52 \ f i i 53 > f | |f 54 c 9 f t 55 * 1 f « .« 56 f 4 4 57 § § & f <> 53 t 1 # § 59 < t 9 9 66 • • t « 61 • • <0 ft 62 - - - - ALL MICE INOCUI AT F O » « 2-3-09 Right ax. with 9*GIcc.of EMULSION OF CARCINOMA 63. E X P.-fivf Fig. 1.—Experiment 63/24 I, showing the immunising effect of preliminary treatment of mice with normal tissues and the abolition of this effect after disintegration of the tissues by freezing and grinding. The numbers represent individual mice treated as stated at the top of each column. The silhouettes represent to scale the sizes of the tumours obtained in each animal at the dates stated, 10, 17, 24, and 31 days after inoculation. Negative results are represented by —. are completely protected, whereas the mice of the third column, treated with ground embryo, developed tumours in each case, i.e. 100 per cent. The some¬ what slower growth of the tumours in the third column, as compared with the controls, may be attributed to an infection, which killed several mice in the same cage, as shown on the chart. The mice treated with fresh skin gave one tumour in 14 mice (i.e. 7 per cent.), whereas the corresponding batch