On the conditions which determine the distribution of the coagulation following the intra-vascular injection of a solution of Wooldridge's tissue fibrinogen / by A.E. Wright.

  • Wright, Almroth, 1861-1947.
Date:
1891
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Licence: Public Domain Mark

Credit: On the conditions which determine the distribution of the coagulation following the intra-vascular injection of a solution of Wooldridge's tissue fibrinogen / by A.E. Wright. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    [From the Journal of Physiology. Vol. XII. No. 2, 1891.] ON THE CONDITlOfHS WHICH/DETERMINE THE DIS- TRIBUTION OFVn^^OJMWLATION FOLLOWING THE INTRAVASCULARfJ^NJECTION OF A SOLU- TION OF WOOLDRIDGE'S TISSUE FIBRINOGEN. By A. E. WRIGHT, B.A., Trin. Coll. Camb., M.D. Univ. of Dublin. Preliminary Commitnication. The injection of a solution of Wooldridge's tissue fibrinogens into the veins of a living dog results in thrombosis of the portal vein and its affluents, the blood in the systemic veins and arteries remaining liquid. These important facts were elicited by Wooldridge1, and only his premature death prevented his following up this fruitful discovery. The observations which are to be communicated here will perhaps contribute towards carrying his work a step further. Wooldridge while describing the usual result of an injection of tissue fibrinogen to be the coagulation of the blood in the portal district alone, had not failed to observe that if the injection were made into an animal during active digestion coagula were also found in the right heart and in the pulmonary artery. The hypothesis which he put forward tentatively to explain these facts was, that the coagulation that occurred in the portal tract was due to the injected tissue fibrinogen there meeting some body which had been absorbed from the intestinal canal and which favoured coagulation. This body he supposed to be under ordinary conditions completely eliminated from the blood during its passage through the liver. In active digestion however he suggested it would be incompletely held back there, and the coagula found in the right heart would then be due to its overflow into the cardiac blood. This hypothesis, however, becomes untenable in the light of the following facts: 1 Proceedings, Royal Society, 1886.