An experimental inquiry into the relationship of action to dose : especially with reference to repeated administration of indaconitine / by J. Theodore Cash.

  • Cash, John Theodore, 1854-1936.
Date:
1908
Catalogue details

Licence: In copyright

Credit: An experimental inquiry into the relationship of action to dose : especially with reference to repeated administration of indaconitine / by J. Theodore Cash. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    lO regarding the time of commencing rise after the Initial fall occasioned by one-half lethal proportions, we note that this takes place In about 75', so that a second dose timed at 90' alter the first—allowing a few minutes lor absorption—would begin to be eflectlve when the rise Is established, and when manifestly the disorder occasioned by the first dose is waning. The temperature-reducing effect of the first dose Is not reproduced by the second, nor Is that of the second reproduced by the third when the time interval Is of 120' or longer, whereas If the time Interval Is short (45') a progressive Increase Is recorded. A glance at the subjoined table will make this clear: Propor- tion to Lethal. Number of Doses. Time Interval. Greatest Reduetlon of Kectal Temperature. Lowest Temperature recorded below Normal after each one of three Doses. 1. 2. 3, i 3 45' 3.8° C. 0 9° 2.3° 3 8° 1 9 3 90' 28 1.5 2.8 1.2 i 3 120' 1.2 1 2 10 0.9 i 240' 1.2 1.2 0.7 0.6 Readminittration of One third of the Lethal Dote, The average reduction of temperature for a single administration of this proportion is 0.95°. Recovery to the normal Is complete In 130' to 160'. Table taken from a Series of Observations in zohich such a Dose zoas twice readministered at varying Time Intervals (see also Fig. 4). Propor- tion to Lethal. Number of Doses. Time Interval. *s Greatest Reduc- tion of Rectal Tempera- ture. Time of greatest Reduction. Notes. 1 3 3 45' 2° C. After third dose — i 3 60' 1.7 After third dose — 1 3 3 75' 1.4 After second dose — i 3 90' 1.15 — — 1 3 3 120' 0.95 After first dose After second - 0.7° C. I 3 3 240' 0.95 After first dose After second - 0 45° C.
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