The action of thionyl chloride and of phosphorus pentachloride on the methylene ethers of catechol derivatives / by George Barger.

  • George Barger
Date:
[1908]
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: The action of thionyl chloride and of phosphorus pentachloride on the methylene ethers of catechol derivatives / by George Barger. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    3/14
    LI I-—The Action of Thionyl Chloride and of Phosphorus Pentacliloride on the Methylene Ethers of Catechol Derivatives. By George Barger. The synthesis of compounds containing an ortho-dihydroxybenzene nucleus is generally attended with difficulty owing to the instability of this nucleus. On (he other hand, the methylene ethers of many such compounds are easily obtainable from piperonal, which substance, like benzaldehyde, readily undergoes a variety of reactions. The transformation of the methylene ethers into the phenolic compounds presents, however, considerable difficulty. Although (he methylene group is somewhat more easily removed than methyl groups, the usual reagents for the preparation of phenolic compounds from the corresponding alkyl ethers generally bring about the disruption of