Blood groups in man / by R.R. Race and Ruth Sanger.

  • R.R. Race
Date:
1954
Catalogue details

Licence: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Credit: Blood groups in man / by R.R. Race and Ruth Sanger. Source: Wellcome Collection.

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    the gene Jk b = ^/0-2518 = 0-5018 and of the gene Jk a = 1 —0-5018 = 0-4982 and the genotype frequencies will be Jk a Jk a Jk a Jk b Jk b Jk b 0-2482 0-5000 0-2518 or 0-3317! or 0-6683] of all Jk(a j r ) TABLE 85 The Kidd Groups in Boston and in London Allen, Diamond and Niedziela, 1 1951, Boston Total 189 Jk(a+) 146 77-25% Jk(a-) 43 22 - 75 % Race, Sanger, Allen et al., 2 1951, London 201 154 76-62% 47 23-38% Sanger and Race, 7 1953, London 343 253 73-76% 90 26-24% The inheritance of the Kidd groups Assuming that the gene Jk a is capable of expressing itself in single and double dose then the expected distribution of the Kidd groups in parents and offspring can be calculated (Table 86) from the genotype frequencies given above. Table 87 shows the results of testing 117 unselected English families with anti- Jk a ; the expectations are based on Table 86. In Table 88 the families are analysed by Fisher’s method: the agreement between expected and observed in both tables is once again so good that there can be no doubt of the truth of the theory of inheritance. It will be seen that in Table 87 there is one Jk(a-\-) child from a mating Jk(a —) X Jk(a —). The other groups did not show this child to be extra-marital, as it presumably is. The absence of the Jk a antigen from the blood of the parents and its presence in that of the child was confirmed on second samples and by absorption. An antibody which identifies the antigen Jk b , allelomorphic to Jk a The anticipated antibody, anti -Jk b , was first found, in 1953, by Plaut, Ikin, Mourant, Sanger and Race. 6 It was present, together
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