The physiological action of choline and neurine / by F.W. Mott and W.D. Halliburton.
- Frederick Walker Mott
- Date:
- 1899
Licence: Public Domain Mark
Credit: The physiological action of choline and neurine / by F.W. Mott and W.D. Halliburton. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![we have adhered to throughout (1 to 5 cub. centims. of a O'l per cent, solution), are as follows :— ]. Neurine produces a fall of arterial blood-pressure, followed by a marked rise and subsequent fall to the normal level. 2. With small doses the preliminary fall may be absent. 3. With larger doses, by which presumably the heart is more profoundly affected, the rise may be absent. 4. The effect of neurine on the heart of both frog and mammal is much more marked than is the case with choline ; in the case of both alkaloids it is antagonised by atropine. 5. The slowing and weakening of the heart appear to account for the preliminary fall of blood-pressure; though in some cases this is apparently combined with a direct dilating influence on the peripheral vessels. 6. The rise which occurs after the fall is due to the constriction of peripheral vessels, evidence of which we have obtained by the use of oncometers for intestines, spleen and kidney. 7. After the influence of the central nervous system has been removed by section of the spinal cord, or of the splanchnic nerves, neurine still produces its typical effects. 8. After, however, the action of peripheral ganglia has been cut oft’ by the use of nicotine, neurine produces only a fall of blood-pressure. It therefore appears that the constriction of the vessels is due to the action of the drug on the ganglia; in this neurine would agree with nicotine, coniine and piperidine. 9. Section of the vagi produces no influence on the results of injecting neurine. 10. In animals anaesthetised with a mixture of morphine and atropine in addition to chloroform or ether, injection of neurine causes only a rise of blood-pressure. 11. Neurine produces no direct results, so far as we could ascertain, on the cerebral blood vessels. 12. Neurine is more toxic to nerve trunks than choline. 13. Neurine produces a marked effect on the respiration. This is first greatly increased; but with each successive dose the effect is less, and ultimately the respiration becomes weaker and ceases altogether. The animal can still be kept alive by artificial respiration. 14. The exacerbation of respiratory movements will not account for the rise of arterial pressure ; the two events are not synchronous, and an intense rise of arterial pressure (due, as previously stated, to constriction of peripheral blood vessels) may occur when there is little or no increase of resjDiratory activity, or during artificial respiration. 15. As confirmatory of Cervello’s statement that neurine acts like cura.re on the nerve endings of vokmtary muscle, and to which he attributes the cessation of](https://iiif.wellcomecollection.org/image/b22392695_0057.jp2/full/800%2C/0/default.jpg)
