The resolution of hyoscine and its components, tropic acid and oscine / by Harold King.
- King, Harold
- Date:
- 1919]
Licence: Public Domain Mark
Credit: The resolution of hyoscine and its components, tropic acid and oscine / by Harold King. Source: Wellcome Collection.
11/34 page 486
![be converted into the monohydrate, but the reverse change was only effected with difficulty. Both hydrates were afterwards described by Hesse (./. pr. Chem., 1901, [ii], 64, 353), who could subs^at’at6 Gadamer s claims. In reply, Kunz-Krause (ibid. lJf 1 [Hi 64 569) examined Gadamers three-year-old specimens! 54—55°)dlhydrate had m 6Very ^ changed into the base (m. p. 1 he author has not, so far, been successful in obtaining this mono y ra e, so is unable to state with certainty what is the rela- ;on jet ween these two racemic hydrates from the point of view ie partial racemic ester nature of d- and I-hyoscine. e learnij, of these results on the structural formula of oscine o'mula is rrv;tlce' ,Ihe m0St rec6nt and complete ascribes to P?u T 7 ^ ^'> 1918> 51> 1007), who a. cubes to oscine the structure II. CH—0-CH-OH = c8h„02n Where the !i,'king a is regarded as being probably attached to one ol tt Tabilit rtf the.pip6ridiDe The experiments on the stability of the active oscines towards racemising agents 98 a“o77tTPOrt thlS hnklng- pyman and Reynolds (T., 1908, j ~ ave Polnted out the close relationship which exists carboera r°Plne' rT and tel°idine’ a °f contain S thllr 7 and-a hydr°Xyl gr°Up in the molecule. Moreover The ■ H derlvatlves are found together in Datum meteloides. the n 01 't empted to make the suggestion that, like tropine *£%SLm£r*x • anhydride of a trihtdt W° , utherefore be bbe internal be teloidine. The formuL’^gg^ted ale ' tnhydr°Xytropine ma? H H —_1h OH H. -H H H H / / H / 1/ H N Me Tropine. H N _ Me d~ or /[-Oscine ?](https://iiif.wellcomecollection.org/image/b30622074_0011.jp2/full/800%2C/0/default.jpg)
