Researches on morphine. Pt. 1 / by S.B. Schryver and and Frederic H. Lees.

  • Schryver, S. B. (Samuel Barnett), 1869-1929.
Date:
[1900]
Catalogue details

Licence: In copyright

Credit: Researches on morphine. Pt. 1 / by S.B. Schryver and and Frederic H. Lees. Source: Wellcome Collection.

    14/20 (page 1035)
    trated over a free flame, under diminished pressure. If not concen¬ trated too far, crystals of the new hydrochloride will separate out, and these, after filtering off and recrystallising once or twice from hot water, are quite pure. If, however, the new hydrochloride separates as an oil, it is advisable to neutralise carefully the strongly acid liquid with caustic soda and evaporate to dryness in a vacuum. The product thus obtained is then ground up to a tine powder, and extracted with absolute alcohol to separate the hydrochloride of the base from the inorganic salts with which it is mixed. On evaporation of the alco¬ holic extract, a syrup is obtained, which partly solidifies on mixing with water. The solid part can then be collected and recrystallised from water. Owing to the large amount of uncrystallisable matter, the yield of this hydrochloride was very small, and various attempts were made to increase the amount, but without success. As the pro¬ duct could not be obtained in large quantities, it was not subjected to a detailed investigation. The hydrochloride separates from water in glistening needles con¬ taining 1JH20. The base is soluble in ether, but has not yet been investigated. 0-8050, at 120°, lost 0-0665 H20. H.70 = 8-25. 0-1196 gave 0-2707 C02 and 0-0748 H20. 0 = 61-66 ; H = 6*94. 03592 „ 12-8 c.c. moist nitrogen at 19° and 755 mm. N = 4’06. 0-3135*,, 0-1333 AgOl. 01 = 10*52. C^H^OoNjHCljliH^O requires C = 61*35 : 11 = 6-91 : N = 4*21; 01 = 10-7 ; H20 = 8T2 per cent. The specific rotation was determined with a specimen recrystallised from water : aD = + 3°19'; 1=1 dcm. ; c = 2*363; [«.]£= +140-3°. Isomorphine. Isomorphine is most conveniently prepared from bromomorphide. For this purpose, 15 grams of bromomorphide are heated in a reflux apparatus with 150 c.c. of water, care being taken that the suspended base is not superheated, the flask, on this account, being repeatedly shaken. After about 1 hour the whole of the bromomorphide dis¬ appears, and a clear, light brown liquid is formed, which can be partly decolorised by boiling with animal charcoal. After filtering from the animal charcoal, the liquid is concentrated to a syrupy consistence. On stirring, the syrup partly solidifies to a thick, crystalline paste. The crystals are then separated from the mother liquors, washed * This analysis was done by Carius’ method, in order to be sure that there was no> chlorine in the substance other than that in the acid.